Proposed by Lee and Hirst, the phrase ocular surface squamous neoplasia (OSSN) includes the clinical continuum of mild, moderate, and severe dysplasia, carcinoma in situ, and invasive squamous cell carcinoma (SCC).[1] It is important to understand that dysplasia and carcinoma in situ, together constituting conjunctival intraepithelial neoplasia (CIN), are premalignant by definition, and SCC is ...

Bowen's disease, also known as an intraepithelial squamous cell neoplasia, is a carcinoma in situ firstly reported in 1912 by a dermatologist named Bowen from the United States [1]. About 3%~5% of Bowen's disease might develop into invasive squamous cell carcinomas of mocusa and skin [2]. Surgical resection is preferred because of its low recurrence. Here we reported a rare Bowen's disease case...

OBJECTIVE Anal cytology is being increasingly used as part of anal cancer screening in patients at high risk for anal neoplasia. Most studies in anal cytology have focused on correlating the abnormal anal Pap smear with histopathologic outcomes. The aim of this study was to document histopathologic or repeat anal cytology outcomes in patients with unsatisfactory cytology. MATERIALS AND METHOD...

PURPOSE Persistent human papilloma virus (HPV) infection is fundamental for the development of intraepithelial neoplasia and cervical cancer. The aim of this study was to examine the association between HPV infection and cervical cytology, colposcopy, biopsy and the risk factors entailed. METHODS The study included 784 patients tested by in situ hybridization for HPV type 6/11, 16/18 and 31/3...

MATERIAL AND METHODS The current study analyzed the degree of agreement between HPV testing, Pap smear, and colposcopic directed cervical biopsies. The study was performed on a group of 332 patients diagnosed and treated for cervical dysplasia at Cuza-Vodă Obstetrics-Gynecology Clinic Hospital and Suceava County Hospital between 2006 and 2011. RESULTS 190 patients (57.23%) were positive for H...

AIMS To assess the potential value of chromosome in situ hybridisation (CISH), Ki-67, and telomerase immunocytochemistry in liquid based cervical cytology to help detect carcinoma cells and precursors. METHOD Sixty ThinPrep processed cervical cytology samples were studied: 23 cases within the normal limit, 13 low grade squamous intraepithelial lesions (LSILs), 10 high grade squamous intraepit...