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4 Abstract: At physiological oxygen concentrations ([O2]) hypoxia-inducible factor-1α (HIF-1α) is constantly hydroxylated and thus prepared for proteosomal degradation through the action of the prolyl hydroxylases (PHDs) (Jiang et al., 1996). In hypoxia, however, the oxygen-sensitive PHDs are inhibited and HIF-1α is stabilised. Other agents, including cytokines and growth factors have been show...