Candida albicans is an important human fungal pathogen, in terms of both its clinical significance and its use as an experimental model for scientific investigation. Although this opportunistic pathogen is a natural component of the human flora, it can cause life-threatening infections in immunosuppressed patients. There are currently a limited number of antifungal molecules and drug targets, a...

A specific resonance light scattering bioassay for homocysteine is developed on the basis of target-involved assembly of polyethyleneimine-capped Ag-nanoclusters. The bioassay permits discriminating homocysteine from cysteine, glutathione and other amino acids, and allows sensitive and selective detection of homocysteine with a detection limit of 42 nM.

Chemical studies of a Bacillus endophyticus isolated from a Bahamian hypersaline microbial mat led to the isolation of bacillamides B and C, new tryptamide thiazole metabolites. Bioassay-guided fractionation using a HPLC-UV-MS bioassay technique enabled the detection of these trace fermentation products, and their total structures were elucidated by combined spectroscopic techniques.

Abstract. Fouad MR, El-Aswad AF, Aly MI. 2022. Acute toxicity, biochemical and histological of fenitrothion thiobencarb on fish Nile tilapia (Oreochromis niloticus). Nusantara Bioscience 14: 217-226. The results show that the tested are highly toxic to fish. However, is more (1.6 times) Oreochromis niloticus (Linnaeus, 1758) than thiobencarb. determined 96-h LC50 values using a static bioassay ...

The toxicity of malathion to Solea senegalensis was studied in a static renewal bioassay during its first month larval life (between 4 and 30 dph). Through the use different biomarkers biochemical, cellular molecular approaches (inhibition cholinesterases [ChEs], changes cytochrome P450-1A [CYP1A] study histopathological alterations), effects three concentrations (1.56, 3.12, 6.25 μg/L) have be...

The toxicity of the combination xylene and diesel at a 50:50 ratio on African catfish (Clarias gariepinus) was investigated using static bioassay for 96hrs. No significant difference (P>0.05) observed in Physicochemical parameters experimental water after exposure 24 hours among different concentration gradients controlled unit. Although there an increased variation along gradient 96hours. b...

The human monoclonal antibody CP-870,893 is a CD40 receptor agonist currently being developed for the treatment of cancer. A bioassay to measure neutralizing antibodies (Nab) to CP-870,893 in 5% human serum matrix was developed and validated utilizing the Daudi cell line and flow cytometric detection. Additionally, samples from CP-870,893 treated cynomolgus monkeys were analyzed in the bioassay...

Porcine circovirus type 2 (PCV2) is an economically important pathogen. It has been demonstrated that PCV2 DNA can be detected in boar semen by PCR; however, the biological relevance of this is unknown. The objectives of this study were to determine if semen positive for PCV2 DNA is infectious (1) in a swine bioassay, or (2) when used for artificial insemination. For the first objective, 4-week...

abstract due to economical importance of stored product pests and resistance to conventional insecticides, it is necessary to use novel and suitable compounds in control programs. therefore, we evaluated the toxicity of spinosad to three important storage insect, red flour beetle, tribolium castaneum (herbst), rice weevil, sitophilus oryzae (l.), sawtoothed grain beetle oryzaephilus surinamensi...

abstract in a laboratory study the effect of three insecticides (pirimicarb, pymetrozine and spinosad) was evaluated on aphelinus mali a parasitoid of woolly apple aphid. to investigate the contact effect, adults were caged for 16 hours in petri-dishes containing apple leaves sprayed with each insecticide. to determine the oral toxicity in the same period of time, other petri-dishes containing ...