Statins are widely used clinical drugs that exert beneficial growth-suppressive effects in patients with cardiac hypertrophy. We investigated the role of the cell cycle inhibitor p21 (p21) in statin-dependent inhibition of hypertrophic growth in postmitotic cardiomyocytes. We demonstrate that lovastatin fails to inhibit cardiac hypertrophy to angiotensin II in p21 / mice and that reconstitution...

Studies have suggested that statin use is related to cancer risk and prostate cancer mortality. We conducted a population-based cohort study to determine whether using statins in prostate cancer patients is associated with reduced all-cause mortality rates. Data were obtained from the Taiwan National Health Insurance Research Database. The study cohort comprised 5179 patients diagnosed with pro...

Background and Purpose—Previously published meta-analyses exploring the effect of statins on stroke incidence included 20 000 patients and found a 2% to 30% risk reduction. It is not clear whether this is attributable to low-density lipoprotein–cholesterol (LDL-C) reduction. Statin trials have now included 90 000 patients. We have determined the effect of statins and LDL-C reduction on stroke p...

BACKGROUND Statins are cholesterol-lowering drugs, targeting HMG-CoA reductase, thereby reducing the risk of coronary disorders and hypercholesterolemia. However, they also can influence immunologic responses. METHODS Peripheral blood mononuclear cells (PBMCs) and monocyte-derived macrophages (MDMs) were isolated from patients with familial hypercholesterolemia (FH) during statin therapy. Aft...

BACKGROUND Coronary heart disease (CHD) is a major public health problem in the United States. It has been well recognized that patients with prior CHD are at very high risk for recurrent CHD. Statins have been recommended as an effective treatment in the secondary prevention of CHD. OBJECTIVE To (1) determine the proportion of patients who received outpatient statin therapy after CHD hospita...

BACKGROUND Adherence with maintenance drug therapy such as HMG-CoA reductase inhibitors (statins) is typically analyzed from the perspective of patient characteristics. OBJECTIVE To determine the effects of physician and pharmacy characteristics in addition to patient characteristics on variation in adherence rates for 4 statin drugs (atorvastatin, pravastatin, rosuvastatin, and simvastatin) ...

BACKGROUND The authors estimated trends in 1-year case-fatality of stroke in relation to changes in vascular risk management from 1997 to 2005. METHODS A cohort study was implemented using data for 407 family practices in the UK General Practice Research Database, including subjects with first acute strokes between 1997 and 2005. One-year case-fatality was estimated by year and sex. Rate rati...

Background: There is evidence that statins are potent and effective agents with several pleiotropic effects for treatment of coronary artery disease(CAD). Statin may have adverse effects, if given in higher doses and in combinations. Methods: Internet search till 2009 and discussion with colleagues. Results: Statins are wonder drugs influencing wide range of physiological, biochemical,and biolo...

The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q (a component of the electron transport chain in mitochondria), dolichols (important for N-linked glycosylation of proteins) and isoprenoids (important for the membrane association of small GTPases). This thesis concerns novel findings about the effect of statin on ...

To date, hypolipidemic drugs of the statin group are among most popular therapeutic agents used for prevention and treatment common worldwide atherosclerotic cardiovascular diseases (CVD). Therefore, considerable attention researchers is focused on statins to study additional effects these drugs, which accompanied by discovery new mechanisms action properties that should be taken into account o...