In this paper, we investigate the causality in sense of Granger for functional time series. The concept series is defined, and a statistical procedure testing hypothesis non-causality proposed. based on projections dynamic principal components use multivariate test. A comparative study with existing procedures shows good results our An illustration real dataset provided to attest performance pr...

The Hamiltonian of a holonomically constrained dynamical many-particle system in Cartesian coordinates has been recently derived for applications in statistical mechanics [G. R. Kneller, J. Chem. Phys. 125, 114107 (2006)]. Using the same projector formalism, we show here the equivalence of the corresponding equations of motion with those obtained from a Newtonian and a Lagrangian description. I...

Randomized trials in which the unit of randomization is a community, worksite, school or family are becoming widely used in the evaluation of life-style interventions for the prevention of disease. The increasing interest in adopting a cluster randomization design is being matched by rapid methodological developments. In this paper we describe several of these developments. Brief mention is als...

Data generated by the numerous clinical trials conducted annually worldwide have the potential to be extremely beneficial to the scientific and patient communities. This potential is well recognized and efforts are being made to encourage the release of raw patient-level data from these trials to the public. The issue of sharing clinical trial data has recently gained attention, with many agree...

Emotional numbness remains an empirically supported and theoretically intriguing pattern of response to social exclusion that warrants further research, and it would be a loss to the field if such research were prematurely terminated or hampered by the unwarranted conclusions from misleading meta-analyses. The meta-analyses by Gerber and Wheeler (2009, this issue) are based on a biased sample t...

BACKGROUND The importance of valid and reliable assessment of student competence and performance is gaining increased recognition. Provision of valid patient-based formative assessment is an increasing challenge for clinical teachers in a busy hospital setting. A formative assessment tool that reliably predicts performance in the summative setting would be of value to both students and teachers...

More than a dozen randomized controlled trials and several meta-analyses have provided strong empirical support for routine outcome monitoring (ROM) in clinical practice. Despite current enthusiasm, advances in implementation, and the growing belief among some proponents and policymakers that ROM represents a major revolution in the practice of psychotherapy, other research has suggested that t...

The replicate variability of meta-analyses of controlled clinical trials has been assessed as a measure of scientific precision. 46 of 91 known meta-analysis papers were divided into 20 cohorts of studies of the same therapies. Ten cohorts contained meta-analyses with different statistical conclusions; 14 contained differing clinical conclusions with a wider spread than the statistically differ...

Standard meta-analyses are an effective tool in evidence-based medicine, but one of their main drawbacks is that they can compare only two alternative treatments at a time. Moreover, if no trials exist which directly compare two interventions, it is not possible to estimate their relative efficacy. Multiple treatments meta-analyses use a meta-analytical technique that allows the incorporation o...