Novel, functionalized piperazine derivatives were successfully synthesized and fully characterized by 1H/13C/19F NMR, MS, elemental analysis and lipophilicity. All piperazine compounds occur as conformers resulting from the partial amide double bond. Furthermore, a second conformational shape was observed for all nitro derivatives due to the limited change of the piperazine chair conformation. ...

The West Palaearctic genus Nothris is reviewed. Eight species are distinguished, and adults and genitalia are described and figured. Two species are described as new for science: Nothris gregerseni sp. n. and N. skyvai sp. n. New synonymies are established: Nothris discretella Rebel, 1889 syn. n. and N. verbascella clarella Amsel, 1935 stat. n. are considered synonyms of N. verbascella ([Denis ...

MISSION (ARM): QUANTATIVE IRON MINERALOGY AND OXIDATION STATES. C. Schröder, G. Klingelhöfer, R. V. Morris, A. S. Yen, F. Renz, and T. G. Graff, Biological and Environmental Sciences, University of Stirling, Stirling FK9 4LA, Scotland, UK, [email protected], Institute of Inorganic Chemistry and Analytical Chemistry, Johannes Gutenberg-University, Staudinger Weg 9, 55128 Mainz, Germ...

cis-3-Acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones were prepared through a Staudinger [2+2]-cyclocondensation between acetoxyketene and the appropriate epoxyimines in a highly diastereoselective way. Subsequent potassium carbonate-mediated acetate hydrolysis, followed by intramolecular ring closure through epoxide ring opening, afforded stereodefined 3-aryl-4-hydroxy-2-oxa-6-azabicyclo[3.2.0]he...

FROM JAROSITE AT MERIDIANI PLANUM TO GOETHITE AT GUSEV CRATER. G. Klingelhöfer, D.S. Rodionov , R.V. Morris, C. Schröder, P.A. de Souza, D.W. Ming, A.S. Yen, B. Bernhardt, F. Renz, I. Fleischer, T. Wdowiak, S.W. Squyres, and the Athena Science Team. Institut für Anorganische und Analytische Chemie, Johannes Gutenberg-Universität, Staudinger Weg 9, D-55128 Mainz, Germany, [email protected]...

For more than two decades, the Center for Lifespan Psychology has promoted a perspective on behavioral development that seeks to integrate age periods, domains of functioning, timescales, and levels of analysis. In part through these efforts, lifespan psychology has evolved into a distinct conceptual approach within developmental psychology (e.g., Baltes, 1987; Baltes, Lindenberger, & Staudinge...

N-Myristoyl transferase-mediated labelling using a substrate modified with an azide or alkyne tag is described as an efficient and site-selective method for the introduction of a bioorthogonal tag at the N-terminus of a recombinant protein. The procedure may be performed in vitro, or in a single over-expression/tagging step in vivo in bacteria; tagged proteins may then be captured using Staudin...

A recently developed proteomics strategy, designated tagging-via-substrate (TAS) approach, is described for the detection and proteomic analysis of farnesylated proteins. TAS technology involves metabolic incorporation of a synthetic azido-farnesyl analog and chemoselective derivatization of azido-farnesyl-modified proteins by an elegant version of Staudinger reaction, pioneered by the Bertozzi...

To facilitate structural and dynamic studies of G protein-coupled receptor (GPCR) signaling complexes, new approaches are required to introduce informative probes or labels into expressed receptors that do not perturb receptor function. We used amber codon suppression technology to genetically-encode the unnatural amino acid, p-azido-L-phenylalanine (azF) at various targeted positions in GPCRs ...