background: stem-cell technology has been advocated as a potentially curative option for treatment of both type 1 and type 2 diabetes. in the current study, we aimed to assess the effectiveness of allotransplantation of fetal liver-derived cells for treatment of patients with type 1 diabetes. methods: for the purpose of the current study, 72 patients with recently diagnosed type 1 dm were recru...

background: niche cells, regulating spermatogonial stem cells (sscs) fate are believed to have a reciprocal communication with sscs. the present study was conducted to evaluate the effect of ssc elimination on the gene expression of glial cell line-derived neurotrophic factor (gdnf), fibroblast growth factor 2 (fgf2) and kit ligand (kitlg), which are the main growth factors regulating sscs deve...

introduction: to evaluate the camp -mediated ibmx (3-isobutyle -1-methyl xanthin) and db-camp (dibutyryl camp) effects on differentiation of human embryonic stem cells (hescs) into nerve cells were the objectives of this study. methods: we have used royan h1 hesc- derived embryoid bodies with four treatment groups: six days treatment with ibmx (5×10 -4m) and db-camp (10 -9m) (referred to as cam...

background: the aim of this study was to investigate the percentage of the stem cells population in human endometrial tissue sections and cultured cells at fourth passage. methods: human endometrial specimens were divided into two parts, one part for morphological studies and the other part for in vitro culture. full thickness of human normal endometrial sections and cultured endometrial cells ...

naturally the brain is ineffective in regenerating functional tissue after disease or injury, so to overcome these defects innovative curative strategies such as stem cell transplantation and tissue engineering have to be considered. researchers investigate the use of strategies to attain better functional repair results. one of the important challenges of effective transplantation is the deliv...

cord blood hematopoietic stem cells are widely used as an alternative source for hematopoietic stem cells transplant. increasing rate of patients who need hematopoietic stem cells transplant and many advantages of cord blood in comparison to bone marrow hematopoietic stem cells, have promoted banking of cord blood units. cord blood banking requires accurate steps in donor selection, cord blood ...

objective: one of the major issues in bone tissue engineering is the design and fabrication of bioactive, bioresorbable porous 3d scaffolds capable of maintaining their structure and integrity over a predictable period of time. one such approach is the fabrication of composite scaffolds. methods: in this study we present fabrication and characterization of novel silk/bioglass-composite scaffold...

background: vhl (von hippel-lindau), runx-3 (runt-related transcription factor 3), e-cadherin (epithelial cadherin), p15 (ink4a, cyclin dependent kinase inhibitor), and p16 (ink4b) genes are essential in hematopoiesis. the aim of this study was to explore the correlation between gene expression and promoter methylation in cd34+ stem cells before and after differentiation to erythroid lineage. m...

background: in most mammals, the testis is always maintained at a lower temperature than that in the abdomen, and exposure of the testis to body temperature causes degeneration of germ cells. objective: in this research, the long effect of heat exposure on sperm parameters and microstructure of mouse testis were investigated. cryptorchid mouse were induced by exposure to abdominal heat. materia...

Regenerative medicine is a field of focused on the repair or replacement damaged diseased cells, tissues, and organs through use various medical technologies. These technologies include stem cell therapy, tissue engineering, gene among others. Millions across globe are plagued with musculoskeletal disorders (MSD) ranging debilitating effects that detrimental to functionality one's life. The hea...