BACKGROUND Dilatation of the ascending aorta in aortic stenosis may be partly explained by intrinsic wall structure changes, but the relative contribution of altered hemodynamics is unclear. The aim of this study was to assess the association between ascending aortic dimensions and valve stenosis severity. METHODS AND RESULTS An analysis of echocardiographic examinations was conducted in 296 ...

In order to establish a new echocardiographic index of the severity of mitral stenosis, left ventricular echocardiograms were digitised using manual tracing and a computer. The instantaneous left ventricular dimension was measured in 15 patients with mitral stenosis. The peak rate of change of left ventricular dimension (peak dD/dt) and the normalised peak rate (peak dD/dt/D) during early diast...

rheumatic heart disease is a serious health problem in developing countries. the present study was conducted to evaluate clinical and echocardiographic findings of mitral stenosis and their relationship with patients functional classes. we studied records of 400 patients with symptomatic mitral stenosis (71% female, mostly in 20s or 30s and 54% function class ii) treated in two hospitals in teh...

The prevailing vascular fluid dynamics plays an important role in the development of atherosclerosis which is one of the most wide spread disease in humans. The recent advances in computational fluid dynamics (CFD) can be useful in observing the flow behavior downstream of the stenosis. The present study investigates a simple case of 66% eccentric stenosis of an approximate model generated from...

The Cholesterol Lowering Atherosclerosis Study, a randomized angiographic clinical trial, demonstrated the beneficial effect of niacin/colestipol plus diet therapy on coronary atherosclerosis. Outcome was determined by panel-based estimates (viewed in both still and cine modes) of percent stenosis severity and change in native artery and bypass graft lesions. Computer-based quantitative coronar...

PURPOSE To correlate vibration frequency and duration at Doppler vibrometry with stenosis severity determined at catheter angiography. MATERIALS AND METHODS Sixteen patients (eight women) scheduled to undergo abdominal or pelvic angiography were recruited after providing informed consent. An ultrasonography (US) scanner was customized to acquire raw echo data before conventional Doppler proce...

Traditionally, arterial stenoses have been assumed to be inflexible, static obstructive lesions that could not acutely change their configuration or cross-sectional area. However, recent clinical and experimental observations have shown that coronary arterial stenoses can respond to vasoconstriction and intraluminal pressure changes. This experimental study evaluated whether similar dynamic cha...

The pressure drop across a stenotic vessel is an important parameter in medicine, providing a commonly used and intuitive metric for evaluating the severity of the stenosis. However, non-invasive estimation of the pressure drop under pathological conditions has remained difficult. This study demonstrates a novel method to quantify the irreversible pressure drop across a stenosis using 4D Flow M...

Many problems and complications associated with heart valves are related to the dynamic behavior of the valve and the resultant unsteady flow patterns. An accurate depiction of the spatial and temporal velocity and rms distributions imparts better understanding of flow related valve complications, and may be used as a guideline in valve design. While the generalized correlation between increase...