LONG, JAMES F., AND FRANK P. BROOKS. Relation between inhibition of gastric secretion and absorption of fatty acids. Am. J. Physiol. 2og(3) : 44745 I. 1965. -Gastric secretion stimulated by a 100-g meat meal was inhibited by oleic acid and triolein and the inhibition correlated with absorption of the respective lipids in dogs with vagally innervated gastric pouches. Twentysix milliliters of lip...

LONG, JAMES F., AND FRANK P. BROOKS. Relation between inhibition of gastric secretion and absorption of fatty acids. Am. J. Physiol. 2og(3) : 44745 I. 1965. -Gastric secretion stimulated by a 100-g meat meal was inhibited by oleic acid and triolein and the inhibition correlated with absorption of the respective lipids in dogs with vagally innervated gastric pouches. Twentysix milliliters of lip...

Effects of KW-5805, a new antiulcer agent, on various experimental ulcers, necrotizing agent-induced gastric lesions and gastric acid secretion in rats were compared with those of pirenzepine and cimetidine. KW-5805 showed antiulcer activities against experimental gastric and duodenal ulcers (ED50 = 1.2-10.0 mg/kg, p.o.). KW-5805 effectively inhibited gastric lesions induced by various necrotiz...

In our previous papers (1, 2), we reported that a new fraction of licorice root (FM 100) showed a protective effect on ulceration in the pylorus ligated rats and gastric antisecretory activities in rats and dogs in spite of being devoid of anticholinerigc properties. FM 100 decreased non-stimulated gastric secretion volumes and acid outputs in the pylorus ligated rats and gastric acid secretion...

OBJECTIVE Thyroid hormones affect gastric acid secretion. As the mechanism of this effect has not been fully known, in this experimental study the isolated gastric acid secretion of hypothyroid and hyperthyroid rats were compared with control group by the administration of different doses of pentagastrin, histamine and carbachol as gastric acid secretion stimulators. METHODS This study was ca...

Teaching gastrointestinal physiology to preclinical medical students presents problems in finding suitable practical exercises to demonstrate the physiology of gastric acid secretion. In our course, students measure their own gastric secretory activity by the use of nasogastric tubes. Gastric secretion can be stimulated by insulin-induced hypoglycemia or by pentagastrin, a synthetic gastrin ana...

We examined the role of prostaglandin E (EP) receptor subtypes in the regulation of gastric acid secretion in the rat. Under urethane anesthesia, the stomach was superfused with saline, and the acid secretion was determined at pH 7.0 by adding 50 mM NaOH. The acid secretion was stimulated by intravenous infusion of histamine or pentagastrin. Various EP agonists were administered intravenously, ...

Epidermal growth factor (EGF) has acute inhibitory and chronic stimulatory effects on gastric acid secretion. Because a cascade of intracellular events culminating in the activation of a family of serine-threonine protein kinases called extracellular signal-regulated protein kinases (ERKs) is known to mediate the actions of EGF, we undertook studies to explore the functional role of the ERKs in...