OBJECTIVE Our population-based research aimed to clarify the association between chronic kidney disease (CKD) and mortality risk in patients with lung cancer. DESIGN Retrospective cohort study SETTING: National health insurance research database in Taiwan PARTICIPANTS: All (n=1 37 077) Taiwanese residents who were diagnosed with lung cancer between 1997 and 2012 were identified. Eligible pati...

a r t i c l e i n f o This paper explores the emerging role of the supply chain manager (scm) towards strategic supply chain relationship manager (scrm), where the emphasis moves from managing processes to managing relationships with suppliers. We posit that changes in role require changes in both management approaches and the skill requirement of role players. We review the literature related ...

COX-2 inhibitory activities of some 1,4-dihydropyridine and 5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives were modeled by quantitative structure–activity relationship (QSAR) using stepwise-multiple linear regression (SW-MLR) method. The built model was robust and predictive with correlation coefficient (R2) of 0.972 and 0.531 for training and test groups, respectively. The quality of the mod...

Standard quantitative trait loci (QTL) mapping techniques commonly assume that the trait is both fully observed and normally distributed. When considering survival or age-at-onset traits these assumptions are often incorrect. Methods have been developed to map QTL for survival traits; however, they are both computationally intensive and not available in standard genome analysis software package...

BACKGROUND Transcatheter arterial chemoembolization (TACE) is the most widely used treatment option for unresectable hepatocellular carcinoma (HCC). Elevated serum YKL-40 level has been shown to predict poor prognosis in HCC patients undergoing resection. This study was designed to validate the prognostic significance of serum YKL-40 in patients with HCC undergoing TACE treatment. METHODS Ser...

BACKGROUND Odds ratios (OR) significantly overestimate associations between risk factors and common outcomes. The estimation of relative risks (RR) or prevalence ratios (PR) has represented a statistical challenge in multivariate analysis and, furthermore, some researchers do not have access to the available methods. OBJECTIVE To propose and evaluate a new method for estimating RR and PR by l...

In large cohort studies, it often happens that some covariates are expensive to measure and hence only measured on a validation set. On the other hand, relatively cheap but error-prone measurements of the covariates are available for all subjects. Regression calibration (RC) estimation method (Prentice, 1982, Biometrika 69, 331-342) is a popular method for analyzing such data and has been appli...

In these days, increasing consumer demand uncertainties, e.g. due to war in Europe, severe drought west Europe or Covid pandemic, increase challenge supply chain operation. Uncertainty and unreliable events interfere chain’s operations strategies. As a result, risks becomes vulnerable leads undesired circumstance. A systematic approach is therefeore required manage the risks. Of many methods, r...

Objectives The Cox proportional hazards (PH) model is commonly used in randomised clinical trials (RCTs) to assess a treatment effect after adjusting for known prognostic factors. However, the Cox model requires that a covariate effect is constant over time. Violation of this assumption invalidates the simple Cox model. Various PH checks exist, some in the form of statistical tests and some emp...