T HE MARKED INCREASE in the number of bone marrow lymphocytes of the guinea pig,13 and mouse,4 during a period of posthypoxic polycythemia ( rebound) has been extensively investigated. Although there was evidence of lymphocyte production in the rebound bone marrow of the guinea pig,5 the mechanisms by which the lymphocytic bone marrow was formed were not satisfactorily determined. In order to d...

Abstract Background Polycythemia vera (PV) is characterized by red cell mass expansion in the peripheral blood and can be complicated with thrombosis, bleeding, evolution to acute myeloid leukemia (AML) or a fibrotic phase. Paroxysmal nocturnal hemoglobinuria (PNH) an acquired clonal haematopoietic stem disorder associated chronic intravascular hemolysis, venous defective hematopoiesis, frequen...

Abstract Purpose The main aim of this study was to detect the presence JAK2 mutation and its assessment in relation clinical, hematological, mutational profile young patients with established polycythemia. Methods Cross-sectional observational undertaken over a period 1 year tertiary care center. Sixty were included our between age 18 50 years confirmed diagnosis polycythemia vera. Reports all ...

Polycythemia vera is a myeloproliferative neoplasm that can cause opposite complications: thrombosis and bleeding. Since arterial or venous often fatal, prevention of thrombogenesis the main treatment measure for polycythemia vera, both in daily life perioperatively. However, reports bleeding are less frequent than thrombosis. Herein, we report case which significant postoperative was periopera...