Periodontitis is a common inflammatory disease, which is initiated by bacterial infection and subsequently progressed by aberrant host response. It can result in the destruction of teeth supporting tissues and have an influence on systemic health. When periodontitis occurs, reactive oxygen species, which are overproduced mostly by hyperactive neutrophils, could not be balanced by antioxidant de...

1 Laboratory of Chromatin Structure and Functions, Engelhardt Institute of Molecular Biology RAS, Moscow 119991, Russia 2Department of Biology, Technion – Israel Institute of Technology, 32000 Haifa, Israel 3Department of Biochemistry and Molecular Biology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel Aviv, Israel 4Department of Microbiology & Immunology, Universi...

Chronic stress has been shown to alter behaviour in both humans and rodents. For example, previous studies have shown that chronic stress can impair skilled motor function in animals. The stress response is defined by an increase in stress hormones, cortisol in humans and corticosterone (CORT) in rodents, both secreted by adrenal glands. CORT can cross the blood brain barrier easily to regulate...

In this issue of Clinical Science, Steptoe et al. [1] report that acute psychological stress in humans (computerized colour-word interference task and mirror tracing) significantly increases the serum concentrations of interleukin-6 (IL-6) and the IL-1 receptor antagonist (IL-1Ra). IL-6 is a pleiotropic cytokine which is involved in T-cell activation, B-cell differentiation and the initiation o...

Discovery Medicine, Volume 5, Number 26, Pages 165-169, April 2005 There is an extensive body of scientific literature related to the field of research called psychoneuroimmunology. Clinical studies, backed up by mechanism studies, have provided convincing evidence that the central nervous system (CNS) interacts with the endocrine and immune systems and that these interactions are bi-directiona...

background: hypoactive sexual desire disorder is the most common sexual disorder among women, which interferes with their various functions. activity of brain-behavioral and psychological distress systems are considered among factors affecting sexual function. objectives: the present study aimed to compare women with hypoactive sexual desire and normal women in terms of brain-behavioral and psy...

background: this paper proposes a new emotional stress assessment system using multi-modal bio-signals. electroencephalogram (eeg) is the reflection of brain activity and is widely used in clinical diagnosis and biomedical research. methods: we design an efficient acquisition protocol to acquire the eeg signals in five channels (fp1, fp2, t3, t4 and pz) and peripheral signals such as blood volu...

Arsenic (As), a metalloid and unnecessary element, is highly toxic to living organisms. It can be accumulated in the environment and enter the food chains through uptake by plants. The present study was designed to assess the response of antioxidant defense system of alfalfa to As (As0, As3+ and As5+) induced oxidative stress at four rates (0, 100, 200, and 300 µM) as a completely randomized de...