We describe direct effects of strontium ranelate on the interaction of osteoblastic cells with different titanium substrates. Our goal was to better understand the potential of this drug for improving the efficacy of bone implants. Treatment was done with 0.12 and 0.5 mM Sr(2+) of strontium ranelate in cell culture. We analyzed cell response to the drug on titanium substrates with surface topog...

The production of radiostrontium in relatively high yield from fission reactions, together with the aflinity of strontium for bone, have added to the need for a quantitative understanding of the behavior of this element in the food chain leading to human bone. The quantity of this fission product which may be maintained in the bone tissue without perceptible damage to the organism is not well d...

Effectively addressing marijuana trade is aided by understanding marijuana geographic sources. We analyzed the (87)Sr/(86)Sr of marijuana samples grown in 79 counties across the United States to determine if a primary geologic signal is retained in marijuana, which could therefore be useful for geographic sourcing. The marijuana results were compared with modeled bedrock (87)Sr/(86)Sr values ba...

The silk fibroin (SF) nanofibrous membrane is a good candidate for clinical application in bone and periodontal regenerative therapy. Strontium (Sr), as a natural element in human bone, can hinder osteoclast activity and promote bone formation. This study aims to evaluate in vitro and in vivo the feasibility of strontium-loaded silk fibroin nanofibrous membrane (Sr-SFM) for guided bone regenera...

The calcium ion is required for the operation of a number of physiological processes, such as bone and tooth formation, blood coagulation, nerve impulse transmission, and muscle contraction. At the cellular-biochemical level, the calcium ion participates in signal transduction and is a significant factor in cell replication and cell division. The ultimate source of this important element is the...

Strontium isotope sourcing has become a common and useful method for assigning sources to archaeological artifacts.In Chaco Canyon, an Ancestral Pueblo regional center in New Mexico, previous studiesusing these methods have suggested that significant portion of maize and wood originate in the Chuska Mountains region, 75 km to the West [corrected]. In the present manuscript, these results were t...

Objectives. The aim of the present paper was to review the published literature in order to identify all relevant studies for inclusion and to determine whether there was any evidence of the efficacy of strontium and potassium toothpastes in the treatment of dentine hypersensitivity (DH). Methods. Following a review of 94 relevant papers both from searching electronic databases (PUBMED) and han...

Bioactive glasses are known to stimulate bone healing, and the incorporation of strontium has the potential to increase their potency. In this study, calcium oxide in the 45S5 bioactive glass composition was partially (50%, Sr50) or fully (100%, Sr100) substituted with strontium oxide on a molar basis. The effects of the substitution on bioactive glass properties were studied, including density...

The presence of strontium in the bone tissue of vertebrates has been reported by a number of investigators (l-6), although at least two workers found none in the samples analyzed (7, 8). The behavior of strontium in the animal body is of some interest, for, although its metabolic fate is very similar to that of calcium, it cannot supplant calcium in the diet without causing severe disturbances ...

systemic steroids – initially intravenous hydrocortisone 100 mg 8-hourly for 3 days, followed by oral prednisolone 50 mg a day – as well as topical triamcinolone oral paste and an antiseptic mouthwash. She responded well to treatment. Strontium ranelate is a relatively new medication for the treatment of post-menopausal osteoporosis. It simultaneously increases bone formation and decreases bone...