نتایج جستجو برای: structural bioinformatics
تعداد نتایج: 422175 فیلتر نتایج به سال:
Bioinformatics is a relatively new field concerned with the computational analysis and prediction of properties of biomolecules, DNA, RNA, and proteins, in particular, on a genomic/proteomic scale. Machine learning models play increasingly important roles in development of novel methodologies, summarization, and high-throughput analysis in the bioinformatics field. Advances in the related area,...
The structural elucidations of microbial lipases have been of prime interest since the 1980s. Knowledge of structural features plays an important role in designing and engineering lipases for specific purposes. Significant structural data have been presented for few microbial lipases, while, there is still a structure-deficit, that is, most lipase structures are yet to be resolved. A search for...
UNLABELLED The database SCOP (Structural Classification Of Proteins) has become a major resource in bioinformatics and protein science. A particular strength of SCOP is the flexibility of its rules enabling the preservation of the many details spotted by experts in the classification process. Here we endow classic SCOP Families with quantified structural information and comment on the structura...
background : cockroaches have been recognized as a powerful indoor allergen. cockroach allergy can be a major factor in serious asthma and nasal allergy. bioinformatics tools have been developed to identify potential allergens. the present study was conducted to identify potential allergens in periplaneta americana (linnaeus). methods : the study focused on the identification of potential all...
Helen M. Berman,* Stephen K. Burley, Wah Chiu, Andrej Sali, Alexei Adzhubei, Philip E. Bourne, Stephen H. Bryant, Roland L. Dunbrack, Jr., Krzysztof Fidelis, Joachim Frank, Adam Godzik, Kim Henrick, Andrzej Joachimiak, Bernard Heymann, David Jones, John L. Markley, John Moult, Gaetano T. Montelione, Christine Orengo, Michael G. Rossmann, Burkhard Rost, Helen Saibil, Torsten Schwede, Daron M. St...
structural repetitive subsequences are most important portion of biological sequences, which play crucial roles on corresponding sequence’s fold and functionality. biggest class of the repetitive subsequences is “transposable elements” which has its own sub-classes upon contexts’ structures. many researches have been performed to criticality determine the structure and function of repetitive su...
Cell cycle progression is tightly controlled by the activity of cyclin-dependent kinases (CDKs) [31]. CDKs are inactive as monomers, and activation requires binding to cyclins, a diverse family of proteins whose levels oscillate during the cell cycle, and phosphorylation by CDK-activating kinase (CAK) on a specific threonine residue [19]. In addition to the positive regulatory role of cyclins a...
Motivation: The data that put the ‘evidence’ into ‘evidence-based medicine’ are central to developments in public health, primary and hospital care. A fundamental challenge is to site such data in repositories that can easily be accessed under appropriate technical and governance controls which are effectively audited and are viewed as trustworthy by diverse stakeholders. This demands socio-tec...
Motivation: Model quality assessment programs are used to predict the quality of modeled protein structures. They can be divided into two groups depending on the information they are using: ensemble methods using consensus of many alternative models and methods only using a single model to do its prediction. The consensus methods excel in achieving high correlations between prediction and true ...
Copyright: © 2012 Nebel JC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Following the completion of the Human Genome Project, came the humbling discovery that humans possess barely more protein-coding gene...
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