Various types of DNA damage, induced by endo- and exogenous genotoxic impacts, may become processed into structural chromosome changes such as sister chromatid exchanges (SCEs) and chromosomal aberrations. Chromosomal aberrations occur preferentially within heterochromatic regions composed mainly of repetitive sequences. Most of the preclastogenic damage is correctly repaired by different repai...

OBJECTIVE Hemodynamic abnormality and disruption of white matter (WM) integrity are significant components in the pathophysiology of multiple sclerosis (MS) lesions. However, the roles of stratified lesions with distinct degrees of hemodynamic and structural injury in disease states remain to be explored. We tested the hypothesis that hemodynamic and structural impairment, as assessed by cerebr...

BACKGROUND Crossed cerebellar diaschisis is the disruption of functional connectivity between cerebrum and cerebellum after hemispheric unilateral brain lesions. In adults and to a lesser extent in children, crossed cerebellar diaschisis has been largely investigated by functional connectivity and demonstrated to influence paretic hand function. OBJECTIVE We aim to demonstrate a disruption in...

Magnetic Resonance-guided Focused UltraSound (MRgFUS) offers an incisionless approach to treat essential tremor (ET). Due to lack of evident internal anatomy on traditional structural imaging, indirect targeting must still be used to localize the lesion. Here, we investigate the potential predictive value of probabilistic tractography guided thalamic targeting by defining how tractography-defin...

After brain lesions caused by tumors or stroke, or after lasting loss of input (deafferentation), inter- and intra-regional brain networks respond with complex changes in topology. Not only areas directly affected by the lesion but also regions remote from the lesion may alter their connectivity-a phenomenon known as diaschisis. Changes in network topology after brain lesions can lead to cognit...

OBJECTIVES By whole-body MRI (WBMRI), we aimed to examine the frequency and distribution of inflammatory and structural lesions in PsA patients, SpA patients and healthy subjects (HSs), to introduce global WBMRI inflammation/damage scores, and to assess WBMRI's reproducibility and correlation with conventional MRI (convMRI). METHODS WBMRI (3.0-T) of patients with peripheral PsA (n = 18) or ax...

background: cutaneous leishmaniasis is an annoying and disfiguring disease affecting around 1,500,000 individuals globally. there are endemic pockets of this disease in taif region. in some patients, lesion often weeps and leads to scar formation. the study was conducted to see the efficacy of fluconazole and itraconazole in the patients of cutaneous leishmaniasis and the effect of these drugs ...

breast cancer is a major public health problem for women in the iran and many other parts of the world. dynamic contrast-enhanced magnetic resonance imaging (dce-mri) plays a pivotal role in breast cancer care, including detection, diagnosis, and treatment monitoring. but segmentation of these images which is seriously affected by intensity inhomogeneities created by radio-frequency coils, is a...

breast lesion segmentation in mr images is one of the most important parts of clinical diagnostic tools. pixel classification methods have been frequently used in image segmentation with two supervised and unsupervised approaches up to now. supervised segmentation methods lead to high accuracy, but they need a large amount of labeled data, which is hard, expensive, and slow to be obtained. on t...

OBJECTIVE The goal of this study was to explore the relationship between language and memory lateralization in patients with epilepsy undergoing the intracarotid amobarbital procedure. METHODS In 386 patients, language lateralization and memory lateralization as determined by laterality index (LI) were correlated with each other. RESULTS Language lateralization and memory lateralization wer...