نتایج جستجو برای: stz induced diabetic rats

تعداد نتایج: 1249609  

Journal: :iranian journal of pharmaceutical research 0
g kumar g.sh banu a ganesan murugesan m rajasekara pandian

the present study investigated the possible protective effect of helicteres isora (sterculiaceae) bark extracts on certain biochemical markers in streptozotocin (stz)-induced diabetes in rats. stz treatment (60 mg/kg/i.p) caused a hyperglycemic state that led to various physiological and biochemical alterations. blood levels of glucose, urea, uric acid and creatinine, plasma levels of albumin a...

Journal: :The American journal of physiology 1999
Axel C Pflueger Jennifer M Gross Franklyn G Knox

We investigated the role of prostaglandins in the renal vascular response to exogenous and endogenous adenosine in control and streptozotocin (STZ) diabetic rats. Exogenous adenosine (0.01-100 nmol) injected into the abdominal aorta decreased renal blood flow (RBF) in a dose-dependent manner to a much greater extent in STZ rats than in control rats ( P < 0.001). Inhibition of prostaglandin synt...

2013
Lin-Yu Wang Hsien-Hui Chung Juei-Tang Cheng

Hibiscus taiwanensis (Malvaceae) is widely used as an alternative herb to treat disorders in Taiwan. In the present study, it is used to screen the effect on diabetic hyperglycemia in streptozotocin-induced diabetic rats (STZ-diabetic rats). The extract of Hibiscus taiwanensis showed a significant plasma glucose-lowering action in STZ-diabetic rats. Stems of Hibiscus taiwanensis are more effect...

2010
Kazuhito Ichikawa Yoshiaki Tagawa Masaomi Kawai Makoto Asamoto Tomoyuki Shirai

The effects of streptozotocin (STZ)-induced diabetes on induction of hepatic preneoplastic lesions by diethylnitrosamine (DEN) were investigated in male Fischer rats. A single dose of STZ was injected intravenously either 2 weeks before or after initiation with DEN. The blood glucose levels were significantly elevated from 1 week after STZ-injection until autopsy. The numbers of GST-P positive ...

Objective(s): Phytochemicals such as polyphenols, alkaloids, and terpenoids, protect against the development of early stages and complications of diabetes mellitus according to various reports. The aim of this study was to measure the anti-dyslipidemic and anti-diabetic effects of Citral on high-fat-diet (HFD) and streptozotocin (STZ) induced diabetic dyslipidemic rats and to see also its effec...

Journal: :African journal of biological sciences 2021

Introduction: Diabetic complications as peripheral neuropathy and delayed wound healing affect patient’s quality of life may lead to amputation. Several mechanisms are involved in mediating these including accumulation Advanced Glycation End Products (AGEs) the subsequent state inflammation which were investigated current study. Methos: A fixed size was induced STZ-diabetic rats effect diabetes...

Journal: :iranian journal of diabetes and obesity 0
khadije zare 1. department of physiology , faculty of veterinary medicine, shahid chamran university of ahvaz, ahvaz, iran seyed reza fatemi tabatabaei 1. department of physiology , faculty of veterinary medicine, shahid chamran university of ahvaz, ahvaz, iran ali shahriari 2. department of biochemistry faculty of veterinary medicine, shahid chamran university of ahvaz, ahvaz ,iran ramezan ali jafari 3. department of clinical sciences; faculty of veterinary medicine, shahid chamran university of ahvaz, ahvaz ,iran

objective: diabetes is a metabolic disorder which impairs carbohydrate and lipid metabolism. it is accompanied by cognition impairment in diabetic patients and animal models. lipids play an important role in nerve membrane composition, structure and function. this study was designed to evaluate the effect of dietary butter and sesame oils on passive avoidance memory of streptozotocin (stz) diab...

2013
Daye Cheng Bin Liang Yunhui Li

The Ginkgo biloba extract (GBE) has been reported to have a wide range of health benefits in traditional Chinese medicine. The aim of this study was to evaluate the antihyperglycemic effects of GBE on streptozotocin- (STZ-) induced diabetes in rats. Diabetes was induced in male Wistar rats by the administration of STZ (60 mg/kg b.w.) intraperitoneally. GBE (100, 200, and 300 mg/kg b.w.) was adm...

2010
Pallab K. Haldar Biswakanth Kar Sanjib Bhattacharya Asis Bala Suresh Kumar Pallab Kanti Haldar

The present study evaluated antidiabetic activity of hydroalcoholic extract of Sansevieria roxburghiana rhizome (HASR) in streptozotocin-induced diabetic rats. Hyperglycemia was induced in rats by streptozotocin (STZ, 65 mg/kg body weight). Three days after STZ induction, diabetic rats received HASR orally at 50 and 100 mg/kg body weight daily for 15 days. Glibenclamide (0.5 mg/kg, orally) serv...

This study aimed to investigate the potency of silymarin (SMN) and melatonin (MEL) on restoring the pancreatic  cells in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were divided into five groups, including: control (C), untreated diabetic (D), SMN-treated diabetic (50 mg/kg, orally), MEL-treated diabetic (10 mg/kg, i.p.), and SMN plus MEL-treated diabetic rats. Diabetes was in...

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