The human skin equivalent model (HSEM) is well known as an attractive alternative model for evaluation of dermal toxicity. However, only limited data are available on the usefulness of an HSEM for nanotoxicity testing. This study was designed to investigate cutaneous toxicity of polystyrene and TiO2 nanoparticles using cultured keratinocytes, an HSEM, and an animal model. In addition, we also e...

Background and Aim: Arsenic exposure to the body through oral, dermal, inhalation routes have a detrimental impact on health, including women’s reproductive health. However, effect of arsenic vulva women is unclear. The present study therefore examined effects long-term uterus inflammation mediated by oxidative stress inflammatory mechanism. ...

Humans are exposed to arsenic (As) primarily from air, food and water. However, elevated inorganic As in drinking water is the major cause of As toxicity. Most of the reports of chronic As toxicity in man focus attention on skin manifestations because of its diagnostic specificity, but As often affects most systems of the body. The clinical manifestations of chronic As intoxication are dependen...

Predictions of carcinogenic activity are made for 30 chemicals currently being assessed for rodent carcinogenicity by the U.S. National Toxicology Program. The predictions are based upon the chemical structure, the anticipated or reported mutagenicity, and the reported sub-chronic toxicity of each chemical. It is predicted that 13 chemicals will be noncarcinogenic to rodents, that 7 will be gen...

This study was carried out to investigate blood biochemical alteration in albino rats after cypermethrin treatment. Nitrogen contents of blood in the albino rats have been influenced by the amount of cypermethrin used for toxicity in the acute (1d) and sub chronic (7,14and21days) treatment in the present investigation. The free amino acid, total protein, urea, urea nitrogen, uric acid and creat...

423 A k-NN Algorithm for Predicting Oral Sub-Chronic Toxicity in the Rat Domenico Gadaleta 1,2, Fabiola Pizzo 1, Anna Lombardo 1, Angelo Carotti 2, Sylvia E. Escher 3, Orazio Nicolotti 2 and Emilio Benfenati 1 laboratory of environmental Chemistry and toxicology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy; Dipartimento di Farmacia − Scienze del Farmaco, Università degl...

Objective(s): Nanosilver is one of the most widely used nanomaterials due to its strong antimicrobial activity. Thus, because of increasing potential for exposure of human to nanosilver, there is an increasing concern about possible side effects of these nanoparticles. In this study, we tested the potential dermal toxicity of nanosilver bandage on serum chemical biomarkers in mice.  Materials a...

purpose: to present a case of bilateral enlargement of eyelids in 29 year old man with sclromyxedema syndrome. case report: a 29- year- old man was referred to labbafinegad clinic with bilateral enlargment of upper and lower eyelids, and foreign body sensation since 9 year ago. investigating of patients history show renal deasese(hematuria ) since 9 year ago. in systemic examination the patient...