Glutamate binds to AMPA receptors within a deep cleft between two globular protein domains (domains 1 and 2). Once glutamate binds, the cleft closes, and agonist-bound structures of the isolated ligand binding core suggest that closure of the binding cleft is sufficiently complete that it essentially prevents ligand dissociation. There is also considerable evidence supporting the view that clef...

OBJECTIVES We used national data to study differences in academic achievement between 5-year-old children with an isolated oral cleft and the general population. We also assessed differences by cleft type. METHODS Children born in England with an oral cleft were identified in a national cleft registry. Their records were linked to databases of hospital admissions (to identify additional anoma...

Introduction: Gold standard for alveolar cleft bone grafting is autogenous bone. Advantage of adding the growth factors to the bone is established, so adding PRF to the autogenous bone may have beneficial effects. Methods:  Platelet-rich plasma admixed with autogenous bone and as a biologic membrane over the bone grafted alveolar cleft was used. Results:  Autogenous bone in all (four cases...

PURPOSE To compare the performance in the abilities of receptive and expressive language of children with cleft lip and palate with that of children without cleft lip and palate with typical 12 to 36-month chronological development. METHOD The sample consisted of 60 children aged 12 and 36 months: 30 with cleft lip and palate diagnosis and 30 without cleft lip and palate diagnosis with typica...

BACKGROUND Retinoic acid (RA) is a key regulator of embryonic development and linked to several birth defects including cleft lip and palate (CLP). The aim was to investigate the effects of RA on proliferation and gene expression of human palatal keratinocytes (KCs) in vitro. METHODS KCs from children with and without CLP were cultured with 2 and 5 μM RA. Proliferation was measured by quantif...

Significant heterogeneity has previously been reported but with no consensus on the prevalence of dental anomalies in subjects with a cleft lip and palate (CLP), thus, the purpose of this study was to investigate the frequency of various dental anomalies in the upper dental arch in different cleft groups. Diagnostic records, i.e., panoramic, occlusal and periapical films, dental casts, and intr...

OBJECTIVES/HYPOTHESIS To evaluate the prevalence and unmet need for cleft lip-cleft palate reconstructive surgery by using incidence. Our hypotheses were that the age of presentation to screening clinics will decrease between 2006 and 2012, and the geospatial distribution of cases will expand to a more rural catchment area. STUDY DESIGN Longitudinal cross-sectional/geospatial distribution stu...

Introduction: Children with cleft lip and/or palate are at increased risk of obstructive sleep apnea. The prevalence of obstructive sleep apnea in this population is unknown. The purpose of this study was to assess the frequency of obstructive symptoms and obstructive sleep apnea diagnosis in the cleft population. We hypothesized that obstructive symptoms present more frequently in children wit...

Tooth disorders in the anterior region of the maxilla are very common among patients with cleft lip, alveolar bone and palate. The authors concentrate on dental disorders, erupting problems and root development, specifying dental anomalies - especially regarding the lateral incisor, central incisor and canine. Disorders may relate to the shape of the tooth, its location, size, number and they c...