Penetration of teicoplanin into serum, heart valves, and subcutaneous and muscle tissues was determined in 22 patients undergoing open-heart surgery. Each patient received 12 mg of teicoplanin per kg of body weight as a 30-min intravenous infusion preoperatively. Within 10 h, serum concentrations of teicoplanin declined from 43.1 to 2.8 microg/ml. Teicoplanin concentrations in subcutaneous tiss...

OBJECTIVE This study assessed the biocompatibility of the Epiphany endodontic sealer prepared with resinous solvent of Epiphany system (Thinning resin) in rat subcutaneous tissues. STUDY DESIGN Polyethylene tubes were filled with the sealer and 4 groups were established: GI, Epiphany prepared with 1 drop of resinous solvent (RS); GII, Epiphany prepared with 1 drop of RS and photoactivated; GI...

background and objective: bruising is the most common complications that resulting from subcutaneous heparin injection. it causes the limitation of injection area, anxiety, disruption of body image, refusing treatment in patients and the reduction in patients trust in nurse. although different methods were suggested to lessen these unwanted complications, unfortunately none of them could decrea...

Engineering functional tissues of clinically relevant size (in mm-scale) in vitro is still a challenge tissue engineering due to low oxygen diffusion and lack vascularization. To address these limitations, perfusion bioreactor was used generate contractile engineered muscles 3 mm-thickness 8 mm-diameter. This study aimed upscale the process 50 mm diameter by combining murine skeletal myoblasts ...

The pulsation of blood vessels in the ear of the rabbit greatly increases the rate of the spread of dye introduced into the subcutaneous tissue. The appearance of edema in tissues perfused at a constant pressure leads to very little increase in the rate of dye spread. By contrast, a rapid interstitial spread of dye occurs in tissues becoming edematous while perfused with a pulsatile flow of blo...

To compare tissue-based pharmacokinetics and efficacy of oral tenofovir disoproxyl fumarate (TDF) versus subcutaneous tenofovir (TFV), macaques were treated for 2 weeks starting 1 week after simian immunodeficiency virus inoculation. Despite lower plasma TFV levels in the oral TDF arm, similar TFV diphosphate levels and antiviral activities were measured in lymphoid cells of most tissues. In in...

Colonoscopy is performed for both diagnostic and therapeutic indications. Although rare, associated complications can be quite serious. The frequency of these complications depends mainly on the skills of the physicians doing the procedure, and the diagnostic or therapeutic indications. Major complications include adverse anesthetic related events, aspiration pneumonia, bleeding, and colonic pe...

The minimally invasive Nuss procedure has become the standard of care for surgical correction of pectus excavatum. Pectus excavatum is the most common congenital deformity of the chest wall. Historically, surgical correction was limited to the Ravitch procedure, an invasive procedure associated with significant drawbacks, where abnormal cartilage was removed and the sternum elevated and stabili...

Laparoscopic hysterectomy is a commonly performed gynecological procedure. Although the outcomes are favorable, severe life threatening complications such as pneumothorax, pneumomediastinum and subcutaneous emphysema can occur during laparoscopy secondary to carbon dioxide insufflation. We report a 46-year-old female who was scheduled for laparoscopic-assisted supra-cervical hysterectomy for ut...

We report the development of subcutaneous emphysema in a middle-aged woman that occurred several hours after she had undergone a dental restoration procedure. The patient presented to the emergency department, and she was admitted for observation and prophylactic antibiotic coverage. She recovered in 3 days without further intervention and was discharged.