Compared to intravitreal injection, subretinal injection has more direct effects on the targeting cells in the subretinal space, which provides a new therapeutic method for vitreoretinal diseases, especially when gene therapy and/or cell therapy is involved. To date, subretinal delivery has been widely applied by scientists and clinicians as a more precise and efficient route of ocular drug del...

The present study introduces a rare case with secondary glaucoma due to anterior chamber lipoma and uveitis in a Pekingese dog in Iran. A four-year-old castrated male Pekingese dog was referred to the private clinic with impaired vision of the left eye, pain, rubbing the left eye onto carpet, presence of a milkycoloured mass into the anterior chamber, and loss of appetite. The clinical examinat...

OBJECTIVE To examine the prevalence and characteristics of uveitis in young adults with juvenile idiopathic arthritis (JIA). METHODS The study population consisted of 123 JIA patients born between 1976 and 1980 whose arthritis had been diagnosed and treatment first started at the Rheumatism Foundation Hospital in 1976 to 1995. A clinical re-evaluation was carried out by an ophthalmologist and...

Introduction: Behcet's disease (BD) is a chronic systemic autoinflammatory vasculitis which is handled by the variety of proteins like cytokines. Therefore, cytokines are considered as one of the prototypic factors during inflammatory responses of BD. Consequently, the present study was designed for evaluation of cytokine profiles in Iranian BD cases, including those with and without uveitis. M...

INTRODUCTION Long-term, high-dose corticosteroid therapy is well-known to cause systemic and ocular complications. A lesser known complication is chronic central serous chorioretinopathy (CSCR). Although idiopathic central serous chorioretinopathy (CSCR) is known to be mild with spontaneous recovery and minimal effects on the final visual acuity, chronic CSCR as a complication of long- term ste...

A 31-year-old man of Asian descent presented with loss of vision in his right eye from 6 months earlier. Best corrected visual acuity (BCVA) was limited to light perception in the right eye and was 6/6, N6 in the left one. Slit lamp examination revealed normal anterior segments bilaterally. Intraocular pressure was 8 and 14 mmHg in the right and left eyes, respectively. Fundus examination in th...

PURPOSE To explore the effects of light exposure and deprivation on the distribution and function of microglia in the subretinal space of mice. METHODS Using a monoclonal antibody, 5D4, that identifies resting, ramified microglia, the distribution and density of microglia in the retina, and the subretinal space were determined by confocal microscopy and by immunohistochemistry of cryopreserve...

Uveitis is considered a rare complication of leptospirosis. This report describes an epidemic of uveitis among patients with leptospirosis and provides data, using polymerase chain reaction (PCR) amplification of Leptospira DNA, that the pathogenesis is associated with anterior chamber spirochetes. Forty-six uveitis patients, 49 uveitis controls, and 54 cataract controls were enrolled at Aravin...