2-Pyridylacetonitrile (1) couples with aromatic diazonium salts to yield arylhydrazones 2a-c, that were shown to exist in the syn-form 2 rather than the anti-form 4. Compounds 2a,c reacted with hydroxylamine in refluxing DMF to yield the interesting 1,2,3-triazolylpyridines 6. Attempts to cyclize 2 to give the corresponding fused pyrazolopyridines 9 failed. On the other hand, compound 1 condens...

Ethyl pyruvate (EP) on reacting with malononitrile or isothiocyanates gives the pyridine derivati ves 5 and 9a , b , respecti vely. Chalcone deri vati ve of EP reacts with malononitrile to yield the pyran derivative which in turn IS transformed into pyridine derivative 14. Reactivity of 5 and 9a towards di fferent organic reagents has been investigated . Antimicrobial activity of some newly syn...

Coupling constants V (I5N 13CR) and V (15N 'H R) in 2-substituted pyridines [R = Me (1), CH = CH2 (2), C = C H (3), C (0)H (4), C (0)M e (5)] have been measured by using 7/ahn-echo extended (H EED) pulse sequences for one(ID ) and two-dimensional (2D ) l3C/'H N M R (HEEDINEPT, HEED-HETCOR). The magnitude of | 2/ ( ,5N 13Cr)| is hardly affected by the hybridiza­ tion o f 13Cr . 15N N M R spectra...

The new synergic base [PMDETA.K(TMP)(Et)Zn(Et)] selectively zincates 4-(dimethylamino)pyridine at the 2-position and 4-methoxypyridine at the 3-position, to afford bimetallic potassium pyridylzinc complexes each displaying a novel, but remarkably different, structure.

The decrease of the number of ring nitrogen atoms of 2-benzylamino-4-methyl-6-trifluoromethyl-1,3,5-triazines on herbicidal activity and inhibition of photosynthetic electron transport (PET) was assayed using thylakoids from Spinacia oleracea or atrazine-resistant Chenopodium album. Three 2-benzylamino-4-methyl-6-trifluoromethyl-1,3,5-triazines, nine pyrimidines with a benzylamino-, methyl- and...

From a pharmacophore model of bicyclic heterocycles as aromatase inhibitors we have designed three series of imidazo[1,2-a]pyridine derivatives. The synthesis and the spectroscopy determination of various compounds are reported. The crystal data of one of these compounds (10b) was obtained. The aromatase inhibition potency was evaluated in vitro and no activity was found.