The effects of cr-amanitin on light induction of the two mRNAs of ribulose-bisphosphate carboxylase/oxygenase (RuBisCO) in greening pea leaves were examined. Induction of the nuclear-coded small-subunit mRNA but not of the chloroplast-coded large-subunit mRNA was significantly reduced by a-amanitin, indicating that the steady-state level of the large-subunit mRNA is not directly affected by tha...

The inhibitory glycine receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on Glycine Receptors) is a member of Cys-loop superfamily transmitter-gated ion channels that includes zinc activated channels, GABAA, nicotinic acetylcholine and 5-HT3 receptors Zn2+- channels. expressed either homo-pentamer α subunits, or complex now thought to harbour 2α 3β subunits [33, 7], contain an intr...

UNLABELLED Bipolar disorder (BD) is a psychiatric disease considered to polygenic with multiple factors in genetics, each of which is not dominant but collaborative during pathogenic progression. We describe a method that estimates the collaborative contribution to the disease between a certain well-studied pathway and the other candidate pathway using Gene Set Enrichment Analysis (GSEA). We de...

Protein phosphatase 2A (PP2A) is a prime example of the multisubunit architecture of protein serine/threonine phosphatases. Until substrate-specific PP2A holoenzymes assemble, a constitutively active, but nonspecific, catalytic C subunit would constitute a risk to the cell. While it has been assumed that the severe proliferation impairment of yeast lacking the structural PP2A subunit, TPD3, is ...

Glycan heterogeneity and subunit composition of therapeutic glycoprotein complexes are challenging to define. In their Communication (e202213170), Di Wu Carol V. Robinson present a native top-down mass spectrometry approach, together with in silico modelling, reveal the stabilization effect interfacial N-glycans on cytokine hormone assemblies.

coagulaon factor xiii gene, protein structure and funcon coagulaon factor xiii (fxiii) is a tetrameric (fxiii- a2b2) pro-transglutaminase enzyme with an essenal role in the final stage of coagulaon cascade by cross linking the fibrin monomers and stabilizing the fibrin clot. congenital fxiii deficiency is a rare bleeding disorder, with an autosomal recessive trait inheritance, and a freque...