Background: Successful aging as an umbrella term with a large amount of literature has emerged with a variety of meanings and dimensions in different studies. This article aims at determining what dimensions contribute to constructing the concept of successful aging.    Methods: The method used in this study is an integrative review of published literature related ...

A uterocutaneous fistula is a rare clinical presentation that occurs following Cesarean section and other pelvic operations. There are only a few reports discussing the treatments. We describe a patient with successful surgical management and review the literature. A 25-year-old woman referred to our department 13 months after her first Cesarean section. She had a history of an abdominal mass a...

In the developed countries, many organizations are regarded a...

Background: Cervical ectopic pregnancy is a rare condition with an incidence of less than 0.1% in all ectopic pregnancies. This life-threatening condition is associated with a high morbidity and mortality rates. Recently, the recommended protocol for the treatment of cervical ectopic pregnancy is fertility preservation rather than invasive surgery and hysterectomy. The aim of t...

Background & Aims: Allergic reaction is a common side effect of Efavirenz and drug replacement may not be an option to physicians. Here, a successful drug desensitization experiment on an 8-year-old female child over a period of 9 days is reported. Case presentation: The patient was an 8-year old female child with HIV in Kerman, Iran who had been received oral efavirenz together with lamivudine...

The problem of how to maximize growth of wealth was solved over half a century ago by Kelly and Breiman: maximize the expected value of the logarithm of wealth after each period. However, as living organisms we have evolved to maximize gene replication, not wealth. Natural selection is a slow process, so our minds today are adapted to seeking our ultimate goal of reproduction in the environment...

Hypernatremia reflects a net water loss or a hypertonic sodium gain, with inevitable hyperosmolality. Severe symptoms are usually evident only with acute and large increases in plasma sodium concentrations to above 158-160 mmol/l. Importantly, the sensation of intense thirst that protects against severe hypernatremia in health may be absent or reduced in patients with altered mental status or w...

One year ago, the American Society for Clinical Investigation (ASCI) launched JCI Insight. I am pleased to report that the last year has been a resounding success for the Society’s newest journal. Let me begin with some background. In my inaugural editorial, I laid out the rationale for JCI Insight (1). In brief, its mission is two-fold: to provide an additional forum for ASCI members and other...