Tie treatment of influenzal meningitis, particularly in a young child, was usually unsuccessful before the introduction of the sulphonamides, serum, and antibiotics. These agents have altered the prognosis, but the choice of one or more of them is not easy, nor is the success attending each invariably predictable. Tlis uncertainty of therapeutic response is much greater in cases which are diagn...

This article describes the Pulsed-field gel electrophoresis clustering of the predominant Salmonella strains (Salmonella ser. Albany, Salmonella ser. Brancaster, and Salmonella ser. Corvallis) isolated from poultry and processing environment in wet market and small-scale processing plant in Penang and Perlis, the northern states of Malaysia. Agar disk diffusion assay was performed to determine ...

Antibiotic resistance among Escherichia coli isolates from diarrhoeal disease in cattle was studied. Many of the isolates were multiply resistant to beta-lactams, including expanded-spectrum cephalosporins, aminoglycosides, sulphonamides, tetracycline and fluoroquinolones. In many of the isolates, IEF revealed a strong beta-lactamase band compatible with overexpression of the AmpC beta-lactamas...

The in-vitro action of the sulphamethoxazole/trimethoprim combination (cotrimoxazole) against coliforms, Proteus spp, and Staphylococcus aureus was re-examined. In nutrient broth the components of cotrimoxazole did not produce bacteriostatic synergy against most sulphonamide-resistant and a significant proportion of sulphonamide-sensitive strains. Any bactericidal action appeared to be due to t...

With the advent of the sulphonamides and of penicillin the treatment of gonorrhoea has again entered into the routine work of the general practitioner who in the past era of "grands lavages was rather reluctant to undertake it. The problems encountered in this field by ptactitioners land venereologists and the methQds of dealing with "them formed one of the subjects of a postgraduate course of ...

Two hundred and thirty-two strains of Escherichia coli belonging to infantile enteropathogenic serotypes isolated in the United Kingdom during 1980 and 1981 were tested for resistance to 10 antimicrobial drugs. Resistance to one or more drugs was found in 134 (57.8%) of the strains, with resistance to sulphonamides, streptomycin, tetracycline, and ampicillin occurring most commonly. Resistance ...

Sulphonamides are an important class of heterocyclic compounds which possess wide spectrum of biological properties.The present work deals with the synthesis of some novel Sulphonamide derivatives using acetanilide, chlorsulphonic acid and various aromatic amines. All the synthesized compounds were characterized by IR, 1 H NMR and 13 C NMR Spectroscopy. The compounds were evaluated for their an...