The universe we observe is homogeneous on super-horizon scales, leading to the “cosmic homogeneity problem”. Inflation alleviates this problem but cannot solve it within the realm of conservative extrapolations of classical physics. A probabilistic solution of the problem is possible but is subject to interpretational difficulties. A genuine deterministic solution of the homogeneity problem req...

Background Intestinal angiodyspalsia is a vascular artero-venous malformation of the enteric wall smaller than 1 cm whose main symptom is enterorrhagy. Diagnosis is based on colonoscopy and mesenteric selective arteriography. Recently, spiral angio-CT has reached a good diagnostic sensitivity and specificity. Radical treatment is still surgical resection. Endoscopic approaches are frequently em...

Melatonin was discovered to be a direct free radical scavenger less than 10 years ago. Besides its ability to directly neutralize a number of free radicals and reactive oxygen and nitrogen species, it stimulates several antioxidative enzymes which increase its efficiency as an antioxidant. In terms of direct free radical scavenging, melatonin interacts with the highly toxic hydroxyl radical wit...

The liver is one of the major target organs affected in sepsis that are usually accompanied with free radical formation. The use of minus charge for the prevention and cure of various radical related diseases is gaining wide importance in the medicinal field. Here, we investigate whether minus charge stimulation (MCS) inhibits nitric oxide (NO) production induced by lipopolysaccharide (LPS) in ...

Ethanol increases free radical formation; however, it was recently demonstrated that it also causes extensive hypoxia in rat liver in vivo. To address this issue, it was hypothesized that peroxynitrite formed in normoxic periportal regions of the liver lobule has its reactivity enhanced in hypoxic pericentral regions where the pH is lower. Via this pathway, peroxynitrite could lead to free radi...

This study examined the average surface roughness (Ra, microm) of 2 microfilled (Durafill and Perfection), 1 hybrid (Filtek Z250) and 2 packable composite resins (Surefil and Fill Magic), before (baseline) and after eight different finishing and polishing treatments. The surface roughness was assessed using a profilometer. Ten specimens of each composite resin were randomly subjected to one of ...

Using the spin trap alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone, we have detected a lipid-derived carbon-centered free radical generated from intact L1210 lymphoblastic leukemia cells that were exposed to 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine or ET-18-OCH3) and oxidative stress. The spectral characteristics, including hyperfine splitting constants of aN = 15.61G an...

The universe we observe is homogeneous on super-horizon scales, leading to the “cosmic homogeneity problem”. Inflation alleviates this problem but cannot solve it within the realm of conservative extrapolations of classical physics. A probabilistic solution of the problem is possible but is subject to interpretational difficulties. A genuine deterministic solution of the homogeneity problem req...

Pluronic poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers are grafted with poly(vinyl pyrrolidone) by free radical polymerization of vinyl pyrrolidone with simultaneous chain transfer to the Pluronic in dioxane. This modified polymer has both thermal responsiveness and remarkable capacity to interact with a wide variety of hydrophilic and hydrop...

S: Y.Mikhed, J.R. Hickok, D.D. Thomas. Oxygen regulates nitric oxide mediated signaling by determining the rate of synthesis and metabolism of nitric oxide. (Poster). The 18 National meeting of the Society of Free Radical Biology and Medicine, Atlanta, GA, 2011. PUBLICATIONS: J.R. Hickok, S. Sahni, Y. Mikhed, M.G. Bonini, D.D. Thomas. Nitric oxide suppresses tumor cell migration through N-Myc d...