The objective of the study was to prepare vinblastine microparticles by supercritical antisolvent process using N-methyl-2-pyrrolidone as solvent and carbon dioxide as antisolvent and evaluate its physicochemical properties. The effects of four process variables, pressure, temperature, drug concentration and drug solution flow rate, on drug particle formation during the supercritical antisolven...

Supercritical water is favorable medium to carry out diverse reactions, specially focusing on “green chemistry” and environmental applications. The intermolecular structure of water due to hydrogen bond, in these conditions, varies and causes changes in its properties and the properties of its solutions. In order to be able to study the behavior of these solutions, to design hydrolysis and oxid...

Solubilities of some polycyclic aromatic hydrocarbons (PAHs) in supercritical carbon dioxide were measured with a procedure based on a direct on-line combination of a saturation cell to a flame ionization detector. Acenaphthene, anthrance and chrysene were selected as the test solutes. A method was developed and evaluated which enables the measurement of the contribution of solute vapor pressur...

Deoxypodophyllotoxin is present in the roots of Anthriscus sylvestris. This compound is cytotoxic on its own, but it can also be converted into podophyllotoxin, which is in high demand as a precursor for the important anticancer drugs etoposide and teniposide. In this study, deoxypodophyllotoxin is extracted from A. sylvestris roots by supercritical carbon dioxide extraction. The process is sim...

Supercritical carbon dioxide has currently received a lot of attention as attractive media for the production of small and solvent-free particles. Rapid expansion of supercritical solutions (RESS) technique has been paid much attention and has been expected as an effective and environmentally friendly nanoparticle design method. In this study, the production of nanoparticles of RS-(±)-ibuprofen...

There are two types of application for gas chromatography (GC) in the supercritical fluid extraction process. Gas chromatography is a type of supercritical extraction apparatuses which can separate a component from a multi-component mixture during supercritical extraction. Therefore, this application can be the alternative to conventional gas chromatography, which needs high temperatures for th...

We propose to use ultrashort laser pulses to detach intact graphene monolayers from a graphite surface, one at a time. As suggested by a combination of real-time ab initio time-dependent density functional calculations for electrons with molecular dynamics simulations for ions, this athermal exfoliation process follows exposure to femtosecond laser pulses with a wavelength of 800 nm and the ful...

Amine intercalated titanates were synthesized by direct exchange of potassium ions of K2Ti4O9 by alkyl ammonium ions of various alkyl chain lengths. These intercalated solids exfoliate well in alcohols of different alkyl chain lengths and non-polar solvents such as toluene and hexane to yield colloidal dispersions of titanate nanosheets. The longer the alkyl chain of the intercalated amine the ...