Fungal meningitis is a serious disease caused by a fungal infection of the central nervous system (CNS) mostly in individuals with immune system deficiencies. Fungal meningitis is often fatal without proper treatment, and the mortality rate remains unacceptably high even with antifungal drug interventions. Currently, cryptococcal meningitis is the most common fungal meningitis in HIV-1/AIDS, an...

The human skin is a complex organ which plays multiple roles, including protection of the body from external aggressions. However, mechanisms defense are sometimes insufficient, allowing microbial proliferation and tissue invasion. Fungi like filamentous pathogenic dermatophytes or commensal yeasts Malassezia genus cause superficial epidermal infections characterized by various degrees inflamma...

High use of synthetic pesticides has detrimental effects on the environment. An alternative option is application of natural pesticide compounds. The aim of this study was to evaluate the possibility of replacing Vitavax with savory essential oil to inhibit physiological damages to wheat (Triticum aestivum L.) seeds caused by Fusarium oxysprum. A pot experiment was carried out on wheat seeds as...

Candida albicans is the most prevalent opportunistic fungal pathogen in humans causing superficial and serious systemic infections. The infection process can be divided into three stages: adhesion, invasion, and host cell damage. To enhance our understanding of these C. albicans infection stages, this study aimed to predict phenotype-associated genes involved during these three infection stages...

AIMS/BACKGROUND To determine the epidemiological characteristics and risk factors predisposing to corneal ulceration in Madurai, south India, and to identify the specific pathogenic organisms responsible for infection. METHODS All patients with suspected infectious central corneal ulceration presenting to the ocular microbiology and cornea service at Aravind Eye Hospital, Madurai, from 1 Janu...

Hospital construction and renovation activities are an ever-constant phenomenon in healthcare facilities, causing dust contamination and possible dispersal of fungal spores. We reviewed fungal outbreaks that occurred during construction and renovation over the last 4 decades as well as current infection prevention strategies and control measures. Fungal outbreaks still occur in healthcare setti...

BACKGROUND Invasive fungal infections are a major cause of morbidity and mortality in preterm infants. The authors conducted the first prospective, randomised controlled trial of nystatin compared with fluconazole for the prevention of fungal colonisation and invasive fungal infection in very low birth weight (VLBW) neonates. METHODS During a 12-month period, all VLBW neonates were assigned r...

background: acute fulminant fungal sinusitis is a rapidly progressive disease with high mortality (50-80%) and occurring with increasing frequency in patients with acute leukemia. the purpose of the present study was early diagnosis of this le­thal infection. methods: in a cross-sectional study, 142 patients with hematological malignancies were studied immediately by initiation of chemotherapy ...

The yeast Candida albicans is a harmless commensal in most healthy people, but it causes superficial as well as life-threatening systemic infections in immunocompromised patients. C. albicans can colonize or infect virtually all body sites because of its high adaptability to different host niches, which involves the activation of appropriate sets of genes in response to complex environmental si...