Breast cancer is one of the leading causes death in women. develops from milk-producing cells breast tissue. Exosomes have been linked to proliferation, metastasis, chemoresistance, and carcinogenesis, according research. are membrane-bound extracellular vesicles that can be secreted contain a variety contents such as nucleic acid, protein, lipid, etc. MicroRNAs, component exosomes, small non-c...

Radiation therapy provides a means to kill large numbers of cancer cells in a controlled location resulting in the release of tumor-specific antigens and endogenous adjuvants. However, by activating pathways involved in apoptotic cell recognition and phagocytosis, irradiated cancer cells engender suppressive phenotypes in macrophages. We demonstrate that the macrophage-specific phagocytic recep...

Despite the remarkable success and efficacy of immune checkpoint blockade (ICB) therapy against PD-1/PD-L1 axis, it induces sustained responses in a sizeable minority cancer patients due to activation immunosuppressive factors such as myeloid-derived suppressor cells (MDSCs). Inhibiting function MDSCs is critical for successful ICB therapy. Interestingly, lipid metabolism crucial factor modulat...

Circular RNAs (circRNAs) are a class of endogenous noncoding RNA, which were previously considered as byproduct RNA splicing error. Numerous studies have demonstrated the altered expression circRNAs in organ tissues during pathological conditions and their involvements disease pathogenesis progression, including cancers. In colorectal cancer (CRC), multiple been identified characterized “oncoge...

CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing critical role metastasis of CX3CR1 expressing cancer cells. can be expressed both and immune-inhibitory myeloid cells to facilitate their migration. We generated novel monoclonal antibody against mouse that binds blocks CX3CL1-CX3CR1 interaction. next explored immune evasion strategies implemented by axis find it ...

PURPOSE Bone marrow is a special compartment for antitumor immunological memory in patients with breastcancer. Until now, the influence of adjuvant systemic therapy on the immune system has only been investigated in peripheral blood and not in bone marrow. In this study, we analyzed the effect of hormone therapy and chemotherapy on the immune activation status in bone marrow. EXPERIMENTAL DES...

A 69-year-old female with a history of bilateral total hip replacements presented with rigors, fever and sudden onset left groin pain. A pelvic X-ray showed well-fixed implants. Blood results revealed a leucocytosis (white cell count 22.3 × 109 l-1) and elevated C-reactive protein (211 mg/l). Ultrasound-guided aspiration of her left hip grew Streptococcus gordonii No source infection could be i...

N116Y, H-RAS mutant, has dominant negative activity in the RAS function and a suppressive effect on the growth of various types of cancer cells. However, a replication error of N116Y is of potential concern for carcinogenesis in clinical application. To decease the concern, we constructed modified N116Y by deleting the carboxyl terminus, which is necessary for the oncogenic function of Ras. One...

The human CD30-positive anaplastic large (T-) cell lymphoma cell line, KARPAS-299 (DSM ACC31), was established from blast cells in the peripheral blood from a case of non-Hodgkin lymphoma in 1988. We describe the mRNA and surface expression in KARPAS-299 cells of a panel of markers highly restricted to human natural regulatory T-cells and associated with their suppressive activity, including FO...