Abstract: Introduction: Diabetes Mellitus (DM) is one of the most prevalent and chronic illnesses associated with an abnormally high level glucose in body which hazardous to organs. Metformin Hydrochloride (HCl), a biguanide derivative used for Type 2 DM. It has relatively short plasma half-life its regular administration required maintain normal blood diabetic patients. Therefore, sustained-re...

High-amylose corn starch, that contains 70% of amylose chains and 30% of amylopectin, has been used to obtain substituted amylose (SA) polymers. Tablets have been prepared by direct compression, i.e. dry mixing of drug and SA, followed by compression, which is the easiest way to manufacture an oral dosage form. Until now, their controlled-release properties have been assessed only by an in vitr...

The aim was to determine the release-modifying effect of carboxymethyl xyloglucan for oral drug delivery. Sustained release matrix tablets of tramadol HCl were prepared by wet granulation method using carboxymethyl xyloglucan as matrix forming polymer. HPMC K100M was used in a small amount to control the burst effect which is most commonly seen with natural hydrophilic polymers. A simplex centr...

The current treatment approaches for allergic rhinitis are practiced over decades, but the patient quality of life has not yet changed so much. reasons research gaps in pathophysiology disease, proper management disease. Fexofenadine HCl is a second-generation antihistamine drug which half-life about 14.4 h. It useful common symptoms like sneezing, itchy throat, and red eyes individuals sufferi...

in this study, attempts were made to evaluate the effect of various acrylic acid based carbopols on the release profile of a beta-adrenoreceptor blocking drug, propranolol hcl, from matrix-type tablets invitro. for this purpose, tablets containing 160 mg of propranolol hcl along with various amounts of carbopols 934 (c934), 971 (c971), 974 (c974) and pemulen (pem) were prepared using the wet gr...

A well-defined and strictly controlled dissolution rate plays vital role in optimization of sustained release dosage form. For this purpose, a computer optimized technique, based on response surface methodology (RSM) utilizing quadratic equation factorial design has been widely used for designing different pharmaceutical formulations, which requires smaller number experimental runs is less time...

Different formulations of Indapamide 1.5mg sustained release tablets were formulated using wet granulation method using hydrophilic polymer. The tablets were subjected to physicochemical studies, in vitro release studies, kinetic modeling and stability studies to find out the best formulation. The in vitro release studies were conducted for 16 hours using USP 30 apparatus type I (Basket method)...

The Liqui-Mass technology (also known as Liqui-Pellet technology) has shown promising results in terms of enhancing the drug release rate water insoluble drugs a simplistic approach. However, there is no current study on sustained-release formulation using technology. In this study, an attempt was made to produce Liqui-Tablet for first time matrix-based non-volatile co-solvent used investigatio...