BACKGROUND Tolerance and response to antiviral HCV treatment is poor in advanced fibrosis. The aim of this study was to assess SVR rate and its predictive factors in HCV advanced fibrosis patients treated in real life with full dose PEG-IFN plus RBV and to evaluate the adverse events related to treatment. METHODS A multicentric, retrospective study was conducted at six university hospitals. M...

In this paper, the annealing robust fuzzy neural networks (ARFNNs) are proposed to improve the problems of fuzzy neural networks for modeling of the molecular autoregulatory feedback loop systems with outliers. Firstly, the support vector regression (SVR) approach is proposed to determine the initial structure of the ARFNNs. Because of a SVR approach is equivalent to solving a linear constraine...

Genetic variation upstream of the apoptosis pathway has been associated with outcome of hepatitis C virus (HCV) infection. We investigated genetic polymorphisms in the intrinsic apoptosis pathway to assess their influence on sustained virological response (SVR) to pegylated interferon-α and ribavirin (pegIFN/RBV) treatment of HCV genotypes 1 and 3 infections. We conducted a candidate gene assoc...

Traffic volume is a fundamental variable in several transportation engineering applications. For instance, in transportation planning, the annual average daily traffic (AADT) is a primary element that has to be estimated for the year of horizon of the analysis. The huge amounts of money to be invested in designed transportation systems are strongly associated with the traffic volumes expected i...

Quantitative stock selection has become a research hotspot in the field of investment decision. As the data mining technology becomes mature, quantitative stock selection has made great progress. From the perspective of value investment, this paper selects top 200 stocks of A share in terms of market value. With the random forest (RF), financial characteristic variables with significant impact ...

This paper presents a robust approach to identify multi-input multi-output (MIMO) systems. Integrating support vector regression (SVR) and annealing dynamical learning algorithm (ADLA), the proposed method is adopted to optimize a radial basis function network (RBFN) for identification of MIMO systems. In the system identification, first, SVR is adopted to determine the number of hidden layer n...

Chronic hepatitis C is commonly associated with extrahepatic manifestations. Cryoglobulins are observed in 40% to 60% of such patients and their presence seems to modify response to therapy. The new antivirals are greatly improving the sustained virological response (SVR); however, their high cost limits the use, leaving pegylated interferon plus ribavirin (PR) still the standard-of-care therap...

UNLABELLED BACKGROUND AND RATIONALE FOR THE STUDY: We assessed the association of CD4+ T-cell counts and HIV-RNA on sustained viral response (SVR) after therapy with pegylated interferon and ribavirin (PR) in HIV/HCV coinfected patients. We examined two large cohorts of coinfected patients treated with PR in Spain between 2000 and 2008. SVR was defined as undetectable HCV-RNA at 24 weeks after ...

Sales forecasting is very bene ̄cial to most businesses. A successful business needs accurate sales forecasting to understand the market and sales trends. This paper presents a novel sales forecasting model by integrating support vector regression (SVR) and bat algorithm (BA). Since the accuracy of SVR forecasting mainly depends on SVR parameters, we use BA for tuning these parameters because Ba...

The brain renin-angiotensin system plays an important role in the regulation of arterial pressure in response to stress, in part due to activation of AT1 receptors in the hypothalamic median preoptic nucleus (MnPO) by endogenous angiotensin II (ANG II). N-methyl-d-aspartate (NMDA) receptors are also involved in the angiotensinergic signaling pathway through the MnPO. We investigated whether AT1...