نتایج جستجو برای: swi
تعداد نتایج: 2401 فیلتر نتایج به سال:
Susceptibility-weighted imaging (SWI) detects hypointensities due to iron deposition and deoxyhemoglobin. Previously it was shown that SWI detects hypointensities in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS), most of which are due to intravascular deoxyhemoglobin, with a small proportion being due to iron deposition in the central nervous system parenc...
Chromatin remodeling has been newly established as an important cancer genome characterization and recent exome and whole-genome sequencing studies of hepatocellular carcinoma (HCC) showed that recurrent inactivating mutations in SWI/SNF subunits involved in the molecular basis of hepatocarcinogenesis. To test the hypothesis that genetic variants in the key subunits of SWI/SNF complexes may con...
Extracellular cues play crucial roles in the transcriptional regulation of tissue-specific genes, but whether and how these signals lead to chromatin remodeling is not understood and subject to debate. Using chromatin immunoprecipitation assays and mammary-specific genes as models, we show here that extracellular matrix molecules and prolactin cooperate to induce histone acetylation and binding...
The SWI/SNF chromatin-remodeling complex plays an essential role in several cellular processes including cell proliferation, differentiation, and DNA repair. Loss of normal function of the SWI/SNF complex because of mutations in its subunits correlates with tumorigenesis in humans. For many of these cancers, cytotoxic chemotherapy is the primary, and sometimes the only, therapeutic alternative....
Expression of the adenovirus E1A243 oncoprotein in Saccharomyces cerevisiae produces a slow-growth phenotype with accumulation of cells in the G1 phase of the cell cycle. This effect is due to the N-terminal and CR1 domains of E1A243, which in rodent cells are involved in triggering cellular transformation and also in binding to the cellular transcriptional coactivator p300. A genetic screen wa...
Anthracyclines are among the most effective yet most toxic drugs used in the oncology clinic. The nucleosome-remodeling SWI/SNF complex, a potent tumor suppressor, is thought to promote sensitivity to anthracyclines by recruiting topoisomerase IIa (TOP2A) to DNA and increasing double-strand breaks. In this study, we discovered a novel mechanism through which SWI/SNF influences resistance to the...
The possible zones of submarine groundwater discharge (SGD) and seawater intrusion (SWI) along the west coast Kanyakumari in southernmost Indian Peninsula were identified by integrating surface temperature anomaly, water table fluctuation, quality analysis. Temperature map sea from Landsat 8 satellite data, which helped to demarcate SGD areas with significant thermal contrast, exists between di...
Introduction Susceptibility weighted imaging (SWI) is used routinely at clinical field strengths because of its high sensitivity to venous vasculature, blood products, and tissue iron content. This sensitivity is due to the magnetic susceptibility information in the phase images which are used to mask the magnitude images [1]. These susceptibility effects increase with the main magnetic field s...
This study tested the hypothesis that the recall of verbal material (critical material) accompanying semantically well-integrated (SWI) sentences will be superior to the recall of verbal material accompanying semantically poorly integrated (SPI) sentences. Complex sentences were constructed which contained two underlying sentences: a matrix sentence and an embedded sentence. Under the SWI condi...
BACKGROUND The ischemia penumbra area is not easy to be detected accurately using noninvasive imaging methods. OBJECTIVE We aim to assess the diagnostic value of susceptibility-weighted imaging (SWI) for ischemic penumbra in patients with acute ischemic stroke. METHODS A retrospective analysis was carried out in 47 patients with ischemic stroke involving the middle cerebral artery. Mean tra...
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