Although selective serotonin reuptake inhibitors (SSRIs) have gained wide acceptance in the off-label treatment of mental disorders in pregnant women, there seems to be an increased risk for serotonergic adverse effects in newborn infants who are exposed to SSRIs during late pregnancy. Hyponatremia as a result of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a relat...

BACKGROUND AND OBJECTIVES Vaptans (vasopressin V(2)-receptor antagonists) are a new approach for the treatment of hyponatremia. However, their indications remain to be determined, and their benefit compared with that of the usual treatments for the syndrome of inappropriate antidiuretic hormone secretion (SIADH) have not been evaluated. This prospective, long-term study compared the efficacy, t...

INTRODUCTION Hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) during amiodarone therapy is a rare but potentially lethal adverse effect. We report a case of severe hyponatremia associated with amiodarone, and discuss its clinical implications. CASE REPORT An 84-year-old Caucasian man with a past medical history of hypertension and diabetes was adm...

Abstract Objectives: Chronic hypercortisolemia suppresses AVP secretion. Copeptin makes up the C-terminal portion of precursor pre-pro-AVP, is released in stoichiometric amounts with AVP, and a stable surrogate marker AVP.A post-operative increase plasma copeptin was hypothesized to be remission Cushing Disease (CD). Methods: Plasma obtained patients CD before daily first week after transspheno...

the pathophysiology in hypothyroidism, involving impaired renal and cardiovascular functions as well as distortion of hypothalamo-adrenal systems , antidiuretic hormone (ADH)and atrial natriuretic peptide (ANP) release, which play important roles in water and electrolyte metabolisms (2, 3). In hypothyroidism, decreases in free water formation and urine volume, especially following an acute wate...

Background. The Syndrome of Inappropriate Antidiuretic Hormone (SIADH) is considered to be the most common cause of euvolemic hyponatremia. The most common malignancy associated with SIADH is small cell lung cancer. We present a rare case of a patient with SIADH secondary to well differentiated squamous cell carcinoma of the naso-oropharynx. Case. A 46-year-old Caucasian woman presented to emer...