In our experimental studies of DNA hybridization as a function of fishing (exposure) time and the subsequent dissociation of bound oligomers, we compared the behaviors of two syntheses of the 59 mer target (labeled 59A and 59B) and 10 mer ODN (labeled 10A and 10B) in different experiments. The two syntheses yield significantly different results. For instance, the fraction of detectable hybridiz...

BACKGROUND The need for competence training and development in health management and leadership workforces has been emphasised. However, evidence of the outcomes and impact of such training and development has not been systematically assessed. The aim of this review is to synthesise the available evidence of the outcomes and impact of training and development in relation to the competence of he...

Mitomycins are a class of very potent antibacterial and anti-cancer compounds having a broad activity against a range of tumours. They have been used in clinics since the 1960's, and the challenges represented by their total synthesis have challenged generations of chemists. Despite these chemical and medicinal features, these compounds, in racemic form, have succumbed to total synthesis only f...

Synthesis of guanosine 3'-phosphodiesters of 1, N6-ethenoadenosine-2-sulfonate or 1, N6-etheno-2-azaadenosine can be done readily with ribonuclease N1. There is a 10-fold difference in quantum yield between the phosphodiesters and the starting fluorescent nucleosides. This difference provides the basis for the development of a fluorescent assay for nuclease.

A new condensation polymerization route leading to alternating polystannanes is presented. The stoichiometric reaction of tin dihydrides and tin diamides in diethyl ether or toluene under mild reaction conditions afforded three new moderate molecular weight alternating polystannanes, -[Ph2Sn-alt-Sn(n-Bu)2]n-, -[Ph2Sn-alt-SnMe2]n-, -[Me2Sn-alt-Sn(n-Bu)2]n-, in addition to a known homopolymer, -[...

Carbohydrate-containing clusters of various valency were synthesized using transition metal-catalyzed reactions. Thus, Grubbs’ ruthenium benzylidene catalyst was used successfully in olefin self-and cross-metathesis reactions from both O-and C-alkenyl glycopyranosides. The reaction was also used to generate C-linked pseudodisaccharides. Oxidative dimerization of terminal alkynes such as 2-propy...

Thin film sputtering syntheses make new cation disordered Mg–W–N phases. Annealing the films drives ordering, which matches phase produced by bulk synthesis.

The reaction of readily available 1 -methyl-4-nitropyrrole-2- carboxylic acid (1) with thionyl chloride afforded the corresponding acyl chloride 2. The reaction of compound 2 with thiosemicarbazides yielded 1-(1 -methyl-4-nitrop yrrole-2-carbony1)- thiosemicarbazides (3) which cyclized in basic medium to 5-(1-methyl-4-nitropyrrole- 2-y1)-2,4-dihydro-3H- l,2,4-triazole-3- thione 4. Alkylatio...