Breast cancer is one of the worst diseases that affect female people. Long-term treatment with therapy or surgery has a detrimental impact on patient. The algae Kappaphycus alvarezii gotten lot interest as breast medication because it contains chemicals are expected to be anti-cancer. objectives this paper were see how secondary metabolites in interact Nuclear Factor- kappaB protein kinase canc...

Utilizing the simple chromatic techniques, Aldose reductase (AR) was derived from sheep liver. In addition, α-glycosidase Saccharomyces cerevisiae used as enzyme. It determined interactions between compounds and enzymes. Molecular docking method to compare biological activity values of molecules against current study, inhibition effect synthetic isoindol-substitute thiazole derivatives (3a-f) o...

Polycystic ovary syndrome (PCOS) is the most common gynaecological disorder among reproductive-age women. Impaired metabolism of androgens and estrogens one leading causes PCOS. In India, medicinal herbs are being explored for their anti-androgenic anti-estrogenic properties. this study, we have screened seed extracts herbal plant, Caesalpinia bonducella potent inhibitors estrogen testosterone ...

US Food and Drug Administration (USFDA) approved gabapentin as an adjuvant treatment for refractory partial seizures several diverse disorders. The drug has a relatively safe profile is well tolerated; however, awareness required to monitor the patient's medication, its misuse, how approach better patient fate. Despite enormous scientific hypothesis encircling drug, there requisite research fur...

Alzheimer disease (AD) diderita oleh 30-35 juta penderita di dunia dan diperkirakan akan meningkat hingga 400% dalam 30 tahun kedepan Indonesia. Salah satu obat yang telah diterima untuk pengobatan AD diisolasi dari tanaman Galanthus nivalis berperan sebagai inhibitor acetylcholinesterase (AChe), galantamine, memiliki efek singkat. Penerimaan terhadap senyawa herbal semakin luas karena kebutuha...

Viral diseases increasingly endanger the world public health because of transient efficacy antiviral therapies. The novel coronavirus disease 2019 (COVID-19) has been recently identified as caused by a new type coronaviruses. This binds to human receptor through Spike glycoprotein (S) Receptor Binding Domain (RBD). spike protein is found in inaccessible (closed) or accessible (open) conformatio...

Hyper-pigmentation conditions may develop due to erroneous melanogenesis cascade which leads excess melanin production. Recently, inhibition of tyrosinase is the main focus investigation as it majorly contributes This property can be exploited in medicine, agriculture, and cosmetics. Present study aims find a natural safe alternative molecule inhibitor. In this study, human enzyme was modelled ...

Introduction and Aim:Epidermal Growth Factor Receptor tyrosine kinase is a well-known widely studied cancer therapeutic target protein. Based on the reported anticancer activity of pyrimidines, series 13 compounds are designed. In present studythe EGFR domain targeted with designed compounds.
 Materials Methods:With missing residue in crystallized structure, modelled using homology modelli...

Retention behavior of molecules mostly depends on their chemical structure. Retention data of biologically active molecules could be an indirect relationship between their structure and biological or pharmacological activity, since the molecular structure affects their behavior in all pharmacokinetic stages. In the present paper, retention parameters (RM0) of biologically active 1,2-O-isopropyl...