We describe the clinical and pathologic findings of the first reported case of pulmonary botryomycosis in a patient with AIDS. Botryomycosis is an uncommon, chronic, suppurative disease that is often mistaken clinically and histologically for a fungal infection. The patient responded to systemic antibiotic therapy.

application of pressure for 2 min at 125 mmHg and 3-min periods of antibiotic irrigation through the suction tube. Topical antibiotic therapy is controversial, although it is already being applied in many surgical specialties. The combination of NPWT and irrigation with antibiotics has been described sporadically in the literature. However, it has started to be used in abdominal surgery, and se...

After oral administration to humans, eltrombopag undergoes extensive cleavage of its hydrazine linkage to metabolites, which are exclusively eliminated in urine. In vitro, the cleavage pathway was not detected in systems using cytochrome P450 enzymes, renal or hepatic microsomes, or hepatocytes but was readily evident after anaerobic incubation with rodent cecal contents or human fecal homogena...

We present a series of 114 patients with microbiologically-proven chronically-infected total hip replacement, treated between 1991 and 2004 by a two-stage exchange procedure with antibiotic-loaded cement, but without the use of a prolonged course of antibiotic therapy. The mean follow-up for all patients was 74 months (2 to 175) with all surviving patients having a minimum follow-up of two year...

The advent of each new antibiotic is not an unmixed blessing. The advantage of acquiring another agent whose range of antibacterial activity parallels that of already existing antibiotics is somewhat offset by the necessity of re-evaluating the known in the light of the new unknown. And involved is not just the effectiveness of one agent versus another, but the relative cost, potential toxicity...

A 78-year-old female developed microbial keratitis from which corneal scrapings grew dysgonic fermenter 2. The infection initially responded poorly to a combination of topical antibiotics and corticosteroids but healed with intensive antibiotic therapy. There was no systemic predisposition to infection, and only feline exposure had occurred. Close association with a cat probably contaminated th...

The clinical utility of serum procalcitonin (PCT) levels continues to evolve. PCT is regarded as a promising candidate marker for making a diagnosis and antibiotic stewardship in patients with systemic infections. The aim of this review is to summarize the current evidence for PCT in different infections and clinical settings, and to discuss the reliability of this marker when used with validat...

Catheter-related bloodstream infections, exit-site infections, and tunnel infections are common complications related to hemodialysis central venous catheter use. The various definitions of catheter-related infections are reviewed, and various preventive strategies are discussed. Treatment options, for both empiric and definitive infections, including antibiotic locks and systemic antibiotics, ...

Septic bacterial arthritis is an orthopaedic emergency, requiring aggressive management. It is characterised by joint pain, swelling and weakness. Untreated, the condition has significant mortality and morbidity [1]. Delayed treatment leads to increased likelihood of systemic and local sequelae; cartilage can be destroyed within days [2]. Treatment is by urgent and aggressive joint washout, deb...

A healthy 54 year old man was investigated for haematuria. In spite of a proven urinary tract infection a cystoscopy was carried out with no antibiotic therapy. As a result he developed systemic infection leading to two independent, and potentially fatal, complications: vertebral osteomyelitis and a mycotic false aneurysm.