نتایج جستجو برای: t cell inhibitor
تعداد نتایج: 2296471 فیلتر نتایج به سال:
Abstract The advent of immunotherapy has transformed our approach to cancer treatment; however, it is virtually ineffective in glioblastoma (GBM), the most common & malignant brain adults, due part inherently immunosuppressive tumor microenvironment (TME). Recent research identified GBM stem cells (GSCs) as key modulators TME, mainly through activation and recruitment pro-tumor immune (e.g....
The recent introduction of immune checkpoint inhibitor therapy with anti- PD-1 agents has shown encouraging responses in gastrointestinal oncology. However, it is also known to possibly result uncontrolled T cell autoreactivity, leading a broad range related adverse events. We present patient who developed sequential immune-related hematologic and hepatic complications following pembrolizumab f...
Background Because conventional single-cell strategies rely on dissociating tissues into suspensions that lose spatial context, 1 we developed Slide-TCR-seq to sequence both whole transcriptomes and TCRs with 10µm-spatial resolution, & applied it renal cell carcinoma (ccRCC) treated immune checkpoint inhibitors (ICI). Methods combines Slide-seqV2 2 3 —a 10µm-resolution approach utilizing mR...
Purpose: Although significant progress has been made in the treatment of T-cell acute lymphoblastic leukemia (T-ALL), many patients will require additional therapy for relapsed/refractory disease. Cyclin D3 (CCND3) and CDK6 are highly expressed in T-ALL and have been effectively targeted in mutant NOTCH1-driven mouse models of this disease with a CDK4/6 small-molecule inhibitor. Combination the...
تحقیقات مختلف اثبات نموده اند که رشد و محتوای بیوشیمیایی روتیفرها می تواند تحت تاثیر نوع غذا و غلظت مواد غذایی تغییر نماید. ریز جلبک ها به عنوان یکی از منابع غذایی مهم برای کشت روتیفرها به ویژه از لحاظ شاخص های نظیر رشد، بقا، میزان پروتئین، چربی و اسیدهای چرب، ضروری می باشند. لذا تحقیق حاضر جهت مقایسه جلبک خشک (کلرلای پودری) و جلبک های تازه (ایزوکرایسیس گالبانا و نانوکلروپسیس آکولاتا) بر رشد، ت...
Prolonged Ca(2+) entry through Ca(2+) release-activated Ca(2+) (CRAC) channels is crucial in activating the Ca(2+)-sensitive transcription factor NFAT, which is responsible for directing T cell proliferation and cytokine gene expression. To establish whether targeting CRAC might counteract intestinal inflammation, we evaluated the in vitro effect of a selective CRAC inhibitor on T cell cytokine...
Introduction:Among major trauma patients in the emergency department, leading cause of morbidity and mortality is a hemorrhagic shock. The low oxygen flow with hypovolemia believed to play significant role. Hence, supply essential severe massive hemorrhage. This study aimed investigate effect hypoxic condition variable treatments such as pentoxifylline (PTX), glycerol, hypertonic saline (HTS), ...
PURPOSE The dual BCR-ABL/SRC kinase inhibitor dasatinib entered the clinic for the treatment of chronic myeloid leukemia and Ph+ acute lymphoblastic leukemia. Because SRC kinases are known to play an important role in physiologic T-cell activation, we analyzed the immunobiological effects of dasatinib on T-cell function. The effect of dasatinib on multiple T-cell effector functions was examined...
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