Mouse monoclonal antibodies were produced against MT-2 cell line derived from adult T-cell leukemia or human T-cell leukemia virus-rich fraction therefrom. Two IgG1 antibodies, Ta60a and Ta60b, were found to be reactive not only with cell lines derived from adult T-cell leukemia or cutaneous T-cell lymphomas, but also with activated peripheral blood lymphocytes, suggesting the similarity of Ta6...

1. Hanchard B: Adult T-cell leukemia/lymphoma in Jamaica: 19861995. J Acquire Immune Defic Syndr Hum Retrovirol 13:S20, 1996 (suppl 1) 2. Hisada M, Okayama A, Shioiri S, Spiegelman DL, Stuver SO, Mueller NE: Risk factors for adult T-cell leukemia among carriers of human T-lymphotropic virus type I. Blood 92:3557, 1998 3. Yamaguchi K, Seiki Y, Yoshida M, Nishimura H, Kawano F, Takatsuki K: The d...

In this article, a mathematical model describing the growth orterminating myelogenous leukemia blood cancer's cells against naive T-celland eective T-cell population of body, presented by fractional dierentialequations. We use this model to analyze the stability of the dynamics, whichoccur in the local interaction of eector-immune cell and tumor cells. Wewill also investigate the optimal contro...

Patients with adult T-cell leukemia showed altered expression of class I HLA antigen in their peripheral blood lymphocytes. Acute type adult T-cell leukemia showed increased levels of the antigen expression compared to those of control group and smoldering type (P < 0.001 and 0.01, respectively). Natural killer sensitivity of infected cell lines with different levels of class I HLA expression s...

Abbreviations: baboon endogenous virus, (BaEV); bovine leukemia virus, (BoLV); complement fixation, (CF); electron microscopy, (EM); feline leukemia virus, (FeLV); human t-cell leukemia virus, (HTLV); interleukin 2, (IL-2) murine leukemia virus, (MuLV); murine mammary tumor virus, (MMTV); National Cancer Institute, (NCI); polymerase chain reaction, (PCR); radioimmunoassay, (RIA); reverse transc...

Emerging studies suggest that dominant peripheral tolerance is a major mechanism of immune escape in disseminated leukemia. Using an established murine acute myeloid leukemia (AML) model, we here show that systemic administration of recombinant IL-33 dramatically inhibits the leukemia growth and prolongs the survival of leukemia-bearing mice in a CD8+ T cell dependent manner. Exogenous IL-33 tr...