In chick embryo hepatocytes, triiodothyronine (T3) causes a 30- to 40-fold increase in malic enzyme activity when added between 1 and 3 days, but has no effect when added between 5 and 7 days in culture. This transcription-mediated decline in T3 responsiveness is partially reversed by corticosterone (Roncero, C. and A. G. Goodridge, 1992. Arch. Biochem. Biophys. 295: 258-267). Clofibrate also r...

In order to compare the acute effects of three kinds of antithyroid agents of iodide (I-), propylthiouracil (PTU) and PTU combined with iodide (PTU+I-) on thyroid function in hyperthyroid patients with diffuse goiter, serum concentrations of thyroxine (T4), triiodothyronine (T3), T3-resin sponge uptake (T3-RU) and free thyroxine index (FT4I) were employed as thyroid function parameters. In the ...

During the past year, several laboratories have developed monoclonal antibodies reactive with idiotypic-like determinants expressed on human and murine T cell clones, lines, or hybridomas (1-5). These antibodies are felt to react with the antigen receptors of these cells. Such antibodies can mimic the effects of antigen by specifically activating the immunizing T cell, or, under appropriate cir...

Let ω(h, k) be a modulus of continuity, that is, ω(h, k) is a continuous function on the square [0, 2π] × [0, 2π], nondecreasing in each variable, and possessing the following properties: ω(0, 0) = 0, ω(t1 + t2, t3) ≤ ω(t1, t3) + ω(t2, t3), ω(t1, t2 + t3) ≤ ω(t1, t2) + ω(t1, t3). Yu ([3]) introduced the following classes of functions: HH := {f(x, y) : ‖f(x, y)− f(x+ h, y)− f(x, y + k) + f(x+ h,...

We report biodetection of the thyroid hormone triiodothyranine (T3) using carbon nanotube field-effect transistors. T3 molecules bind non-covalently the semiconducting nanotube and donate electrons to the nanotube lattice, thereby altering its electronic characteristics via chemical doping. The effect is semi-reversible by rinsing the transistors with the T3 solvent without the biomolecule. The...

The fidelity of in vitro transcription of bacteriophage T3 DNA by T3 RNA polymerase and Escherichia coZi RNA POlymerase have been studied by DNA-RNA hybridizationcompetition studies with regard to (a) asymmetry of transcription and (b) the region of the T3 DNA transcribed by either polymerase. RNA transcribed by T3 RNA polymerase hybridized exclusively with the H strand of T3 DNA-the only stran...

Early in neocortical network development, triiodothyronine (T3) promotes GABAergic neurons' population increase, their somatic growth and the formation of GABAergic synapses. In the presence of T3, GABAergic interneurons form longer axons and conspicuous axonal arborizations, with an increased number of putative synaptic boutons. Here we show that the increased GABAergic axonal growth is positi...

Late in gestation, the developing air space epithelium switches from chloride and fluid secretion to sodium and fluid absorption. Absorption requires Na-K-ATPase acting in combination with apical sodium entry mechanisms. Hypothyroidism inhibits perinatal fluid resorption, and thyroid hormone [triiodothyronine (T3)] stimulates adult alveolar epithelial cell (AEC) Na-K-ATPase. This study explored...

Thyroid hormones regulate growth, development, differentiation, and metabolic processes by interacting with and activating thyroid hormone receptors and associated pathways. We investigated the triiodothyronine (T3) modulation of gene expression, in human hepatocellular carcinoma cell lines, via a PCR-based cDNA subtraction method. Here we present further data on one of the T3-upregulated genes...

New research is demonstrating that thyroid hormone transport across cellular membranes plays an important role in intracellular triiodothyronine (T3) levels of peripheral and pituitary tissues and is proving to have considerable clinical significance. Reduced T4 and T3 transport into the cells in peripheral tissues is seen with a wide range of common conditions, including insulin resistance, di...