Oxidative stress is one of the important mechanisms involved in Dexamethasone (Dex)-induced hypertension. Protocatechuic acid (PCA) is a natural compound with high antioxidant capacity. In this investigation, the effect of pretreatment with PCA was studied in Dex-induced hypertensive male Wistar rats. For induction of hypertension, Dex was injected subcutaneously for 14 days. PCA (50, 100 and 2...

B lood pressure is regulated through the complex interaction of neural, hormonal, vascular, cardiac, and renal mechanisms, and many advances in understanding this complicated process have come from research using animal models. Environmental factors such as diet, temperature, and even music can significantly alter blood pressure in research animals. Although many of these factors have been inve...

In a previous study, by using a candidate gene approach, we detected in both Milan hypertensive rats and humans a polymorphism in the alpha-adducin gene (ADD1) that was associated with blood pressure and renal sodium handling. In the present study, a genomewide search with 264 informative markers was undertaken in 251 (Milan hypertensive strain x Milan normotensive strain) F2 rats to further in...

Repair of massive rotator cuff tears is technically difficult but often feasible. Technical and biological challenges to a successful repair include inelastic poor-quality tendon tissue, scarring, muscle atrophy, and fatty infiltration. Fatty infiltration of the involved rotator cuff muscles has been identified as an important negative prognostic factor for the outcome after repair of massive r...

A 53-year-old man with a history of a bilateral lung transplantation (LT) at the age of 39 underwent electrophysiological testing of supraventricular tachycardia (SVT). At baseline, the SVT persisted, and exhibited positive P waves in the inferior leads and lead V1. The activation map in the left atrium (LA) revealed a centrifugal pattern from the right pulmonary vein (RPV) cuff ( F1 Panel A). ...

SUMMARY This paper describes a fault in the cuff of a reinforced latex endotracheal tube, where the cuff splits into layers. On attempting to deflate the cuff, the pilot balloon subsides but not the cuff itself. The cause of this fault is examined, and, by implication, steps to eliminate it during manufacture suggested. It would appear that not all such available latex endotracheal tubes are po...

Using spontaneously hypertensive rats (SHR), this study investigated whether electroacupuncture (EA) could reduce early stage hypertension by examining nitric oxide (NO) levels in plasma and nitric oxide synthase (NOS) levels in the mesenteric resistance artery. EA was applied to the acupuncture point Governor Vessel 20 (GV20) or to a non-acupuncture point in the tail twice weekly for 3 weeks u...

To determine whether the area postrema contributes to the development of hypertension in spontaneously hypertensive rats (SHR), sham or electrolytic lesions of the area postrema (AP) were made in 4-week-old SHR and Wistar-Kyoto (WKY) controls. From weeks 5 through 16, systolic pressure was measured via tail plethysmography. While blood pressure rose markedly in sham-operated SHR, increases in p...

Rotator cuff tears are a ubiquitous cause of shoulder pain and disability. Full thickness rotator cuff tears are present in 19-21% of the general population, and their prevalence increases with age. The incidence of this problem is exacerbated by the ever advancing age of our patient population. Thankfully, with advances in arthroscopic rotator cuff repair, this has become a treatable problem w...

The subacromial bursa is recognized as a site associated with the shoulder pain caused by rotator cuff disease in the middle-aged and elderly. Substance P is contained in primary afferent nerves, and its quantity increases during chronic pain. The amount of substance P in the subacromial bursa of patients with rotator cuff disease was examined. Radioimmunoassay and immunohistochemistry were emp...