Tamsulosin hydrochloride sustained-release capsules contained core-shell structure based pellets with tamsulosin as middle layer and the weight of excipients was 800 times more than hydrochloride. Therefore, extraction should release related substances from minimize degradation during extraction. And chromatographic methods be specific to separate their products main In present study, its were ...

OBJECTIVES To evaluate the efficacy of solifenacin, tamsulosin oral-controlled absorption system (OCAS), and the combination of both drugs on JJ stent-related symptoms using the validated Arabic version of the ureteric stent symptom questionnaire (USSQ). PATIENTS AND METHODS In all, 260 patients who had undergone JJ stenting of the ureter for different endoscopic urological procedures were po...

INTRODUCTION In recent years, medical expulsive therapy has been used in the management of distal ureteric stones as a supplement to conservative treatment. Therefore, we conducted a prospective randomized study to evaluate the possible role of tadalafil individually in comparison with proven tamsulosin therapy in ureteric stone expulsion. The aim of this study is to compare the safety and effi...

INTRODUCTION Currently alpha1-adrenoceptor blockers (AB) are widely used as first-line therapy to improve lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). We compared the efficacy and safety profile of tamsulosin, alfuzosin and silodosin in LUTS due to BPH. MATERIAL AND METHODS Consecutive consenting male patients (N = 269) undergoing medical management ...

OBJECTIVE To review the existing evidence regarding the efficacy and safety of medical therapy for lower urinary tract symptoms (LUTS) indicative of benign prostatic hyperplasia (BPH). To assess randomised controlled trials investigating the six alpha-adrenergic receptor antagonists (alpha-blockers), prazosin, alfuzosin, indoramin, terazosin, doxazosin, and tamsulosin, that benefit patients by ...

Objectives: This study was done to determine the efficacy of alpha-1 adrenoceptor blockers such as tamsulosin, alfuzosin, and silodosin in patients with lower urinary tract symptoms (LUTS) due benign prostatic hyperplasia (BPH) over 6 months by assessing change international prostate symptom score (IPSS), quality life scale for (Bother score), improvement peak urine flow rate (Qmax) from baseli...

OBJECTIVES To evaluate the impact of the prostatic-urethral angulation (PUA) on the treatment efficacy of selective alpha-1A receptor blocker in male patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH). MATERIALS AND METHODS A total of 80 patients with LUTS/BPH and with mean age 53.3 ± 6.3 (range 47-70) were included in our prospective comparative s...