Background and aim: Tanacetum parthenium L. is herbaceous perennial medicinal plant belonging to the Asteraceae family. Feverfew is used as an analgesic, housing, fever-lowering, anti-rheumatism and migraines in traditional medicine. The most important active ingredient of the herb is essential oil. Variation on genetic and environmental conditions play a major role in...

Background and aim: Tanacetum parthenium L. is herbaceous perennial medicinal plant belonging to the Asteraceae family. Feverfew is used as an analgesic, housing, fever-lowering, anti-rheumatism and migraines in traditional medicine. The most important active ingredient of the herb is essential oil. Variation on genetic and environmental conditions play a major role in...

Parthenolide (PN) is the principal sesquiterpene lactone in feverfew (Tanacetum parthenium) with proven anti-inflammatory properties. We have previously reported that PN possesses strong anticancer activity in ultraviolet B (UVB)-induced skin cancer in SKH-1 hairless mice. In order to further understand the mechanism(s) involved in the anticancer activity of PN, we investigated the role of prot...

Feverfew is a traditional herbal remedy for a wide range of medical conditions, including migraine and arthritis1−4. The plant contains a large number of natural products, but the active principles probably include one or more of the sesquiterpene lactones known to be present, including parthenolide (Figure 1)5−6. Feverfew can be taken in a variety of forms, including the raw leaf or tablets or...

Chronic cocaine administration leads to catecholamine reuptake inhibition which enhances reward and motivational behaviors. Ventral Tegmental Area dopaminergic (VTA DA) neuronal firing is associated with changes in reward predictive signals. Acute cocaine injections inhibit putative VTA DA cell firing in vertebrates. Parthenolide, a compound isolated from the feverfew plant (Tanacetum partheniu...

Periodontitis is an inflammatory disease that causes osteolysis and tooth loss. It is known that the nuclear factor kappa B (NF-κB) signalling pathway plays a key role in the progression of inflammation and osteoclastogenesis in periodontitis. Parthenolide (PTL), a sesquiterpene lactone extracted from the shoots of Tanacetum parthenium, has been shown to possess anti-inflammatory properties in ...