Purpose: EphA2 is an attractive therapeutic target because of its diverse roles in cancer growth and progression. Dasatinib is a multikinase inhibitor that targets EphA2 and other kinases. However, reliable predictive markers and a better understanding of the mechanisms of response to this agent are

Establishing an effective antimicrobial therapeutic requires choosing the appropriate antibiotic and ensuring compliance with times and doses prescribed. Problems concerning early abandonment and unfinished prescriptions due to lack of information, as well as more resistant microorganisms, have been identified as the major factors responsible for therapeutic failure in bacterial infections. Thi...

In this paper we test the 'red herring' hypothesis for expenditures on long-term care. The main contribution of this paper is that we assess the 'red herring' hypothesis using an aggregated measure that allows us to control for entering the nal period of life on the individual level. In addition we implement a model that allows for age speci c time-to-death (TTD) e ects on Long Term Care. We al...

Placenta-specific protein 1 (PLAC1) is an X-linked gene whose expression is almost exclusively limited to placental trophoblasts. Its expression profile and evolutionary history suggest that it is important in the proper establishment and maintenance of a healthy placenta and a successful gestation throughout the Eutheria through promoting invasiveness, migration and proliferation of placental ...

Traditional concepts of the pathogenesis of acute coronary syndromes have changed over the last few years. In particular it has been demonstrated that highrisk lesions are not necessarily angiographically severe. Rather, unstable high risk lesions are the ones composed of large lipid cores and thin fibrous caps. It is now widely accepted that plaque instability is related to the development of ...

We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The pla...

1The Princess Margaret Hospital, The Ontario Cancer Institute, Toronto, ON; 2Department of Chemistry, University of Toronto, Toronto, ON; 3Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, Toronto, ON; 4Burnham Institute of Medical Research, La Jolla, CA; and 5Banting & Best Department of Medical Research and 6Structural Genomics Consortium, University of...

[1] In this study we investigate an event-scale transit time distribution (TTD) for a catchment located in the Santa Catalina Mountains northeast of downtown Tucson, Arizona, USA, during a series of extreme rainfall events. Traditionally, TTD studies look at the long time response of a catchment to an input variation in tracer concentration. Few studies have determined the TTD at the scale of a...

Integrin receptors have remained as a key subject of interest in the pharmaceutical industry for the last few years. There are a total of 24 different types of integrin heterodimers. Each of these heterodimers plays important role in various biological processes that are inherent to different pathological conditions. As a result, integrin receptors have been extensively evaluated for their role...