CD34+ human marrow cells not expressing T cell-, B cell-, and myeloid cell-associated antigens (TBM-) were cloned by two-color cell sorting into culture wells containing irradiated marrow stromal cells. After 4 wk of culture, 3.7 +/- 2.1% of these cells generated colony-forming cells (CFC), with each of these cells generating 6.3 +/- 5.3 CFC. This was not due to the 0.5 +/- 0.5% CFC present in ...

greater levels of complexity in tunnelling with tunnel boring machine (tbm) allow higher chances of failures that may increase the potential hazardous risks. this paper presents the results of a study on tbm reliability using risk analysis. machinery failure mode and effect analysis was applied to analyze the risks of a tbm using qs9000 and sae.j1739 recommendations. for this purpose, 48 failur...

Computed tomography (CT) is gaining widespread usage as an aid to tuberculous meningitis (TBM) diagnosis for the examination of a number of visual indicators of the disease. We present an algorithm that uses modified fuzzy c-means clustering to segment CT images of the brain into various tissue types. The end result is that hyperdense areas of the brain are delineated, which aids the radiologis...

There are no data about the comparative accuracy of commercially available nucleic acid amplification tests (GeneXpert MTB/RIF and Roche Amplicor) for the diagnosis of tuberculous meningitis (TBM). A total of 148 patients with suspected TBM were evaluated, and cultures served as the reference standard. The sensitivities and specificities (95% confidence interval [CI]) for the Amplicor and Xpert...

To address the issue of whether tri-bimaximal mixing (TBM) is a softly-broken hidden or an accidental symmetry, we adopt a model-independent analysis in which we perturb a neutrino mass matrix leading to TBM in the most general way but leave the three texture zeros of the diagonal charged lepton mass matrix unperturbed. We compare predictions for the perturbed neutrino TBM parameters with those...

In the April 2006 issue of the Journal of Clinical Microbiology, Shah et al. reported the simultaneous presence of Mycobacterium tuberculosis and Mycobacterium bovis in 22 human cerebrospinal fluid specimens (5). The method used to reveal the alleged coinfection was a novel nested PCR (N-PCR) described by Mishra et al. (3). In that original study, N-PCR correlated as poorly with culture (85/189...

BACKGROUND Dexamethasone has been shown to reduce mortality in patients with tuberculous meningitis but the long-term outcome of the disease is unknown. METHODS Vietnamese adults and adolescents with tuberculous meningitis recruited to a randomised, double-blind, placebo-controlled trial of adjunctive dexamethasone were followed-up at five years, to determine the effect of dexamethasone on lo...

BACKGROUND MRI is an important clinical tool for diagnosing dementia-like diseases such as Frontemporal Dementia (FTD). However there is a need to develop more accurate and standardized MRI analysis methods. OBJECTIVE To compare FTD with Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) with three automatic MRI analysis methods - Hippocampal Volumetry (HV), Tensor-based Morphometry...

HIV-associated tuberculous meningitis (TBM) has high mortality. Aside from the devastating impact of multidrug resistance (MDR) on survival, little is understood about the influence of other bacterial factors on outcome. This study examined the influence of Mycobacterium tuberculosis drug resistance, bacterial lineage, and host vaccination status on outcome in patients with HIV-associated TBM. ...

In the present prospective study, a dot immunobinding assay (Dot-Iba) was standardized to measure the circulating mycobacterial antigen in cerebrospinal fluid (CSF) specimens for the laboratory diagnosis of tuberculous meningitis (TBM). Immunoglobulin G antibody specific for Mycobacterium tuberculosis in a CSF specimen from a patient with culture-proven TBM was isolated and was coupled with act...