Introduction The effects of ionising radiation on cells are complex and include cell apoptosis, cell swelling and cell lysis, all of which affect the cellular density. The aim of this study was to investigate if the apparent diffusion coefficient (ADC) changed before and after external beam radiotherapy (EBRT) in response to these effects using similar acquisition techniques to studies that hav...

PURPOSE This study aims to retrospectively evaluate dosimetric parameters calculated as biological effective dose in relation to outcome in patients with cervical cancer treated with various treatment approaches, including radiotherapy with and without surgery. MATERIAL AND METHODS Calculations of biological effective dose (BED) were performed on data from a retrospective analysis of 171 pati...

PURPOSE Elderly patients (65 or older) with cervical cancer often receive suboptimal radio-chemotherapy. Intensity-modulated radiotherapy (IMRT) may improve tolerance to treatment in this setting. This study was designed to compare the treatment-related toxicities and compliance with treatment in patients of cervical cancer treated definitively with RapidArc IMRT in our institute. METHODS AND...

AIM The Multicenter Study Differentiated Thyroid Carcinoma (MSDS) is an ongoing study in Germany, Austria, and Switzerland on the clinical benefit of adjuvant external beam radiotherapy (RTx) for locally invasive differentiated thyroid carcinoma (DTC) in TNM stages pT4 pN0/1/x M0/x (5th ed. 1997). METHODS MSDS was designed as a prospective randomized trial. Patients receive thyroidectomy, rad...

Approximately 60% of cancer patients are treated with external beam radiotherapy at some point during disease management. Despite the extended time frame of fractionated therapy (4–6 weeks), radiation therapy planning is carried out based on information that is currently limited to a single 3D anatomical computed tomography scan at the onset of treatment. This concept may result in severe treat...

INTRODUCTION The current standard for treating operable early stage non-small cell lung cancer is surgical resection and for inoperable cases it is external beam radiotherapy. Lung functions are adversely affected with both the above treatments. CyberKnife treatment limits radiation damage by tracking targets moving with each breath. The effect of CyberKnife treatment on pulmonary function test...

Intraoperative Radiotherapy (IORT) is a form of accelerated partial breast radiation that has been shown to be equivalent to conventional whole breast external beam radiotherapy (EBRT) in terms of local cancer control. However, questions have been raised about the potential of f IORT to produce breast parenchymal changes that could interfere with mammographic surveillance of cancer recurrence. ...

AIMS To evaluate the outcome of intravitreal bevacizumab in the treatment of radiation-induced cystoid macular oedema among patients who underwent external beam radiotherapy for nasopharyngeal carcinoma. METHODS Five patients were recruited. The length of time from the last external beam radiation therapy to presentation ranged from 12 months to 15 years. Intravitreal bevacizumab (1.25 mg/0.0...

The effect of combined radioimmunotherapy (RIT) and fractionated external beam radiotherapy (RT) was assessed in two human colon cancer xenografts, Co112 and LS174T in nude mice. These tumors were selected for being resistant to RIT alone, as is usually the case in the clinical situation. Tumor-bearing mice were treated with a combination of five X-ray fractions over 5 days followed by RIT with...

INTRODUCTION To develop and externally validate a novel nomogram aimed at predicting cancer-specific mortality (CSM) after biochemical recurrence (BCR) among prostate cancer (PCa) patients treated with radical prostatectomy (RP) with or without adjuvant external beam radiotherapy (aRT) and/or hormonal therapy (aHT). MATERIALS & METHODS The development cohort included 689 consecutive PCa patie...