OBJECTIVES The hypothesis of this study was that metabolites of trichloroethylene (TCE), dichloroethylene (DCE) and related compounds were responsible for fetal cardiac teratogenic effects seen when TCE or DCE is consumed by pregnant rats during organogenesis. Identification of teratogenic metabolites would allow more accurate assessment of environmental contaminants and public health risks fro...

BACKGROUND Azithromycin is an azalide antibiotic with an extensive range of indications and has become a common treatment option due to its convenient dosing regimen and therapeutic advantages. Human studies addressing gestational use of azithromycin have primarily focused on antibiotic efficacy rather than fetal safety. Our primary objective was to evaluate the possibility of teratogenic risk ...

The aim of this study was to determine whether the teratogenic effects of radiofrequency (RF) radiation are due to induced hyperthermia at 27.12 MHz. This was achieved by controlling the degree of temperature change and the duration of the elevation at this RF frequency. Pregnant Sprague-Dawley rats, at 9 days gestation were either sham-irradiated or irradiated with continuous shortwave radiati...

Purpose: To evaluate the role of Helicobacter pylori in the pathogenesis of hyperemesis gravidarum, and the value of adding a non teratogenic regimen for its treatment in intractable cases. Methods: Sixty two hyperemesis gravidarum cases were recruited from Ain Shams University out patient clinics. A full history was taken including history of medical disorders as peptic ulcer and history of ch...

The mitomycins were isolated from the broth of Streptomyces caespitosus by Hata, Shimada & Ishu (1957). Mitomycin C, one of a series of chemically related substances, has been most frequently used in experimental and clinical studies. It was found to have a marked antibacterial, antiviral and antitumor activity in animals and man. In humans, mitomycin C has been used with varying success in the...

The assessment of teratogenic effects of chemicals is generally performed using in vivo teratogenicity assays, for example, in rats or rabbits. We have developed an in vitro teratogenicity assay using the zebrafish Danio rerio embryo combined with an exogenous mammalian metabolic activation system (MAS), able to biotransform proteratogenic compounds. Cyclophosphamide (CPA) and ethanol were used...

The pungent natural compound allyl isothiocyanate isolated from the seeds of Cruciferous (Brassica) plants such as mustard is reported to exhibit numerous beneficial health-promoting antimicrobial, antifungal, anticarcinogenic, cardioprotective, and neuroprotective properties. Because it is also reported to damage DNA and is toxic to aquatic organisms, the objective of the present study was to ...

We read with great interest the manuscript by Chan et al. (2003) examining the teratogenicity of hydrosalpinx ¯uid (HF) using a whole rate embryo culture model. Mechanisms of HF formation and its effects on IVF and embryo transfer outcome have been recently reviewed (Ajonuma et al., 2002). Previous studies were conducted during early embryo development when HF that re¯uxed into the uterine cavi...

References Cucinella G , Granese R , Calagna G et al . 2011 . Parasitic myomas aft er laparoscopic surgery: an emerging complication in the use of morcellator? Description of four cases. Fertility and Sterility 96 : e90 – e96 . Epstein JH , Nejat EJ , Tsai T . 2009 . Parasitic myomas aft er laparoscopic myomectomy: case report . Fertility and Sterility 91 : 932.e13 – e14 . Hill DJ , Maher PJ , ...