Francisco Ort-Llorca (1905-1993) was one of the most outstanding Spanish embryologists of the XX century. He was disciple of Henri Rouvire in Paris (France), Alfred Fischel in Vienna (Austria), Walther Vogt in Munich (Germany) and Pedro Ara in Madrid (Spain). From 1935, he was professor of Human Anatomy at the Faculty of Medicine of Cadiz, belonged then to the University of Seville (accidentall...

Two new species of Typhlocharis Dieck, 1869 from the southwest of the Iberian Peninsula included in baetica species group are described: T acutangula n. sp. and T. mixa n. sp. The new species can be easily recognized by the presence of an anterodistal dentiform projection in metatibia (T. acutangula sp.n) and pseudotetramery and a medial tooth in clypeus (T mixta sp.n), features not observed in...

The National Birth Defects Prevention Study is a population-based case-control study. The study has actively sought to identify children with any of 34 specified types of malformation. The mothers of affected and unaffected children have been interviewed with regard to demographic information, lifestyle factors, and exposures. A large number of published studies have appeared and continue to ap...

OBJECTIVE to review the extensive literature pertaining to the reproductive and teratogenic effects of Bendectin and the opinions of the scientific experts for the defense and plaintiff. These data were evaluated with regard to the reproductive risks of Bendectin providing a scientific framework for evaluating the views of the experts in the Bendectin litigation. DESIGN the Bendectin literatu...

letters reproduced here, the book's main focus is on the work of Rayer: five chapters are devoted to meticulous analysis of his contributions to nineteenth-century medical science. It is an impressive collection of observations on a wide variety of subjects: from his doctoral thesis on the history of morbid anatomy to the observations on human and animal teratology. His pioneering studies in co...

The anatomical collection of the Anatomical Museum of Leiden University Medical Center (historically referred to as Museum Anatomicum Academiae Lugduno-Batavae) houses and maintains more than 13,000 unique anatomical, pathological and zoological specimens, and include the oldest teratological specimens of The Netherlands. Throughout four centuries hundreds of teratological specimens were acquir...

Importance: Polymorphic expression of drug metabolizing enzymes affects the metabolism of antidepressants, and thus can contribute to drug response and/or adverse events. Pregnancy itself can affect CYP2D6 activity with profound variations determined by CYP2D6 genotype. Objective: To investigate the association between CYP2D6 genotype and the risk of antidepressant discontinuation, dosage modif...