Inabilities to attain adequate aqueous solubility and stability have made the preparation of a clinically suitable formulation of taxol difficult. Addition of nicotinamide (ND), 2-hydroxypropyl- b-cyclodextrin (HPßCD), polyethylene glycol, (PEG), bile salts (BS, 50:50 sodium cholate: deoxycholate...

Purpose of Study: In the present study, an attempt was made to design and evaluate buccoadhesive bilayer tablets of granisetron hydrochloride (an anti-emetic drug), in order to overcome bioavailability problems, to reduce dose dependent side effects and frequency of administration. Method: Bilayer buccal tablets containing the drug were prepared by direct compression method using combination of...

In the present work, fast disintegrating tablets of prochlorperazine maleate were designed with a view to enhance patient compliance by effervescent method. In this method, mixtures of sodium bicarbonate and anhydrous citric acid in different ratios along with crospovidone (2-10% w/w), croscarmellose sodium (2-10% w/w) were used as superdisintegrants. Estimation of prochlorperazine maleate in t...

NH3 absorption spectra have been recorded from 6460 to 6522 cm 1 at room temperature and 5.5 Torr pressure with an external cavity tunable diode laser. The spectra served (a) as an initial test of a multipass optical assembly mounted in a large vacuum chamber designed for future slit nozzle experiments, (b) to further our understanding of the characteristics, stability and accuracy of our laser...

In the present work, orodispersible tablets of pheniramine maleate were designed with a view to enhance patient compliance by effervescent method. In the effervescent method, mixture of sodium bicarbonate and tartaric acid (each of 12% w/w concentration) were used along with super disintegrants, i.e., pregelatinized starch, sodium starch glycolate, croscarmellose sodium and crospovidone. The pr...

In the present work, fast disintegrating tablets of prochlorperazine maleate were designed with a view to enhance patient compliance by direct compression method. In this method mucilage of Plantago ovata and crospovidone were used as superdisintegrants (2-8% w/w) along with microcrystalline cellulose (20-60% w/w) and directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The ...

In the present work, fast dissolving tablets of fexofenadine hydrochloride were designed with a view to enhance patient compliance by sublimation method. In this method, camphor was used as the subliming agent (upto 30% w/w), crospovidone and croscarmellose sodium (2-8% w/w) were used as superdisintegrants. Estimation of fexofenadine hydrochloride in the prepared tablet formulations was carried...