We report a Chan–Lam coupling reaction of benzylic and allylic boronic esters with primary secondary anilines to form valuable alkyl amine products. Both tertiary can be used as partners, mono-alkylation the aniline occurring selectively. This is rare example transition-metal-mediated transformation alkylboron reagent. Initial investigation into mechanism suggests that transmetalation from B Cu...

In the past decades, more and more enzymes are employed as biocatalysts in industrial processes because of their advantages, such as high efficiency, substrate selectivity and stereoselectivity. Among them, amine transaminases (ATAs) are pyridoxal 5’-phosphate (PLP) dependent enzymes. ATAs have gained attention for their excellent performance in chiral amine synthesis, and their broad substrate...

Conditions to obtain two polymorphic forms by crystallization from solution were determined for the analgesic drug hydro-morphone [C17H19NO3; systematic name: (4R,4aR,7aR,12bS)-9-hy-droxy-3-methyl-1,2,4,4a,5,6,7a,13-octa-hydro-4,12-methano-benzofuro[3,2-e]iso-quinolin-7-one]. These two crystalline forms, designated as I and II, belong to the P212121 ortho-rhom-bic space group. In both polymorph...

Thermodynamic electron-transfer potentials from biology textbooks elucidate the sequence of electron-transfer events in the respiratory chain in mitochondria. In this study, thermodynamic and kinetic oxygen-transfer potentials have been defined and predicted for oxidants and substrates using density functional theory, aiming to rationalize multiple oxygen-transfer events in chemical catalysis, ...

Aliphatic amines can form secondary aerosol via oxidation with atmospheric radicals (e.g., hydroxyl radical and nitrate radical). The particle can contain both secondary organic aerosol (SOA) and inorganic salts. The ratio of organic to inorganic materials in the particulate phase influences aerosol hygroscopicity and cloud condensation nuclei (CCN) activity. SOA formed from trimethylamine (TMA...

Triflic anhydride (Tf2O) is the reagent of choice for the introduction of the trifluoromethylsulfonyl (CF3SO2) group into a variety of organic substrates, and the resulting compounds often have a unique chemical reactivity [1]. A case in point is given by 3-trifloxypropene iminium triflates which are obtained by O-sulfonylation of enaminones with Tf2O [2, 3] and which are suited for transformat...

spheric pressure ionization mass spectrometric analysis of new anionic surfactants: the alkylpolyglucoside esters. Journal of the American Oil Chemists’ Society 72: 1}9. Metcalfe LD (1962) Potentiometric titration of long chain amine oxides using alkyl halide to remove tertiary amine interference. Analytical Chemistry 34: 1849. Milwidsky BM and Gabriel DM (1982) Detergent Analysis. New York: Ha...

As bacterial biofilms are often refractory to conventional antimicrobials, the need for alternative and/or novel strategies for the treatment of biofilm related infections has become of paramount importance. Herein, we report the synthesis of novel hybrid molecules comprised of two different hindered nitroxides linked to the piperazinyl secondary amine of ciprofloxacin via a tertiary amine link...