The all-alkyl α-tertiary amino acid scaffold represents an important structural feature in many biologically and pharmaceutically relevant molecules. Syntheses of this class molecule, however, often involve multiple steps require activating auxiliary groups on the nitrogen atom or tailored building blocks. Here, we report a straightforward, single-step, modular methodology for synthesis esters....

A novel mechanism for trifluoroacetylation in solid-phase peptide synthesis, independent of the coupling step, has been elucidated. It involves the presence of trifluoroacetoxymethyl groups on the resin support, which react with resin-bound amines by an intersite nucleophilic reaction. The trifluoroacetoxymethyl groups are generated from preexisting hydroxymethyl sites during treatment with tri...

Abstract Graphene-oxide (GO) has been recognized as an excellent lubrication material owing to its two-dimensional structure and weak interlayer interactions. However, the functional groups of GO that can contribute anti-friction, anti-wear, superlubricity are yet be elucidated. Hence, further improvement in GO-family materials tribology fields is impeded. In this study, macroscale with a coeff...