matic vein was achieved either by partial ligation ofthe left renal vein in rats and dogs or by surgical destruction of the valve of the left testicular vein in a second group of dogs. 1 mo after partial ligation in the rats and 3 mo after partial ligation or valve destruction in the dogs, testicular blood flow was measured using Strontium 85 (SR-85)-labeled microspheres (15±1.1 ,um). Intratest...

The objective of the current study was to extend previous observations and examine the expression pattern and effects of transforming growth factor alpha (TGFalpha) and epidermal growth factor receptor (EGFR) on embryonic testis morphogenesis and growth. The expression of TGFalpha was determined after morphological sex determination (seminiferous cord formation at embryonic day 13 [ED13]) throu...

objective: the goals of the study are evaluation the effect(s) of food deprivation as a social stress on testis structure. we also investigated the effects of melatonin treatment as an antioxidant component and inequality on the effect(s) of food deprivation. methods: we investigated the improving effects of melatonin and social stress (food deprivation) on 42 male rats in 7 groups including co...

this study was designed to investigate whether administration of zinc sulphate could improve theresponse of mouse testis to degenerative effects of short term exposure heating. fifty-four adult male balb/cmice were anaesthetized and the scrotums of 36 of them were immersed for 15 min in a waterbath at 43°c.immediately after the heating, half of the heated animals (n = 18) were injected with sal...

A 5-day-old hornless goat was referred with dysuria since birth. The scrotum was absent, and a small penis-like structure was seen below the perineal raphe. On the laparotomy, the testicles were found near the inguinal ring- and attached to a uterus-like structure. On histological analysis, the uterus-like structure was blind-end. Germ cells were absent in the testis. The karyotype of this goat...

Cancer-testis antigens are tumor antigens that their expression is almost limited to male germ cells in the testis. Some of cancer-testis antigens are also expressed in the ovary and in trophoblasts. Recently their expression has been seen in different types of tumors. Many pathophysiologic studies suggest that a blood-testis barrier exists in the testis. Because spermatogenesis begins at puber...

PICK1 (protein interacting with C-kinase 1) is a peripheral membrane protein with high expression in brain, testis, pancreas and other neuroendocrine tissues. Male Pick1 knockout mice are completely infertile, with a phenotype resembling the human disease globozoospermia. Since PICK1 is expressed in both testis and neuroendocrine tissues, infertility of Pick1 knockout mice may be due to either ...